biostudies-literatureRipenko VEuropean Research Council14061-14068https://www.ebi.ac.uk/biostudies/studies/S-EPMC8524415biostudies-literatureUnknown86(20)<i>In flow</i> photochemical addition of propellane to diacetyl allowed construction of the bicyclo[1.1.1]pentane (BCP) core in a 1 kg scale within 1 day. Haloform reaction of the formed diketone in batch afforded bicyclo[1.1.1]pentane-1,3-dicarboxylic acid in a multigram amount. Representative gram scale transformations of the diacid were also performed to obtain various BCP-containing building blocks-alcohols, acids, amines, trifluoroborates, amino acids, <i>etc</i>.-for medicinal chemistry.The Journal of organic chemistryLarge-Scale Synthesis and Modifications of Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acid (BCP).PMC8524415101000893101000893 - BENOVELTYKlymov IMykhailiuk PKZhersh SRipenko VVysochyn DfalseLarge-Scale Synthesis and Modifications of Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acid (BCP).<i>In flow</i> photochemical addition of propellane to diacetyl allowed construction of the bicyclo[1.1.1]pentane (BCP) core in a 1 kg scale within 1 day. Haloform reaction of the formed diketone in batch afforded bicyclo[1.1.1]pentane-1,3-dicarboxylic acid in a multigram amount. Representative gram scale transformations of the diacid were also performed to obtain various BCP-containing building blocks-alcohols, acids, amines, trifluoroborates, amino acids, <i>etc</i>.-for medicinal chemistry.2021-01-01T00:00:00Z2021 Oct2025-04-21T14:52:24.829Z2024-11-19T19:07:47.554ZS-EPMC85244153416659410.1021/acs.joc.1c00977