{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["86(20)"],"submitter":["Franco F"],"pubmed_abstract":["A continuous flow approach to access α-trifluoromethylthiolated esters and amides using commercially available arylacetic acids and <i>N</i>-(trifluoromethylthio)phthalimide as the electrophilic reagent is described. The experimental protocol involves the in-flow conversion of the carboxylic acid into <i>N-</i>acylpyrazole followed by the α-trifluoromethylthiolation in a PTFE coil reactor and final reaction with primary or secondary amines, or alcohols, to afford in a telescoped process α-substituted SCF<sub>3</sub> amides and esters, respectively, in good overall yield and short reaction times."],"journal":["The Journal of organic chemistry"],"pagination":["14207-14212"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8524418"],"repository":["biostudies-literature"],"pubmed_title":["Continuous Flow Synthesis of α-Trifluoromethylthiolated Esters and Amides from Carboxylic Acids: a Telescoped Approach."],"pmcid":["PMC8524418"],"pubmed_authors":["Franco F","Puglisi A","Benaglia M","Lattanzi A","Meninno S"],"additional_accession":[]},"is_claimable":false,"name":"Continuous Flow Synthesis of α-Trifluoromethylthiolated Esters and Amides from Carboxylic Acids: a Telescoped Approach.","description":"A continuous flow approach to access α-trifluoromethylthiolated esters and amides using commercially available arylacetic acids and <i>N</i>-(trifluoromethylthio)phthalimide as the electrophilic reagent is described. The experimental protocol involves the in-flow conversion of the carboxylic acid into <i>N-</i>acylpyrazole followed by the α-trifluoromethylthiolation in a PTFE coil reactor and final reaction with primary or secondary amines, or alcohols, to afford in a telescoped process α-substituted SCF<sub>3</sub> amides and esters, respectively, in good overall yield and short reaction times.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-18T17:28:11.34Z","creation":"2025-04-07T04:59:03.87Z"},"accession":"S-EPMC8524418","cross_references":{"pubmed":["34314582"],"doi":["10.1021/acs.joc.1c01270"]}}