biostudies-literatureUnknown86(20)Franco FA continuous flow approach to access α-trifluoromethylthiolated esters and amides using commercially available arylacetic acids and <i>N</i>-(trifluoromethylthio)phthalimide as the electrophilic reagent is described. The experimental protocol involves the in-flow conversion of the carboxylic acid into <i>N-</i>acylpyrazole followed by the α-trifluoromethylthiolation in a PTFE coil reactor and final reaction with primary or secondary amines, or alcohols, to afford in a telescoped process α-substituted SCF₃ amides and esters, respectively, in good overall yield and short reaction times.The Journal of organic chemistry14207-14212https://www.ebi.ac.uk/biostudies/studies/S-EPMC8524418biostudies-literatureContinuous Flow Synthesis of α-Trifluoromethylthiolated Esters and Amides from Carboxylic Acids: a Telescoped Approach.PMC8524418Franco FPuglisi ABenaglia MLattanzi AMeninno SfalseContinuous Flow Synthesis of α-Trifluoromethylthiolated Esters and Amides from Carboxylic Acids: a Telescoped Approach.A continuous flow approach to access α-trifluoromethylthiolated esters and amides using commercially available arylacetic acids and <i>N</i>-(trifluoromethylthio)phthalimide as the electrophilic reagent is described. The experimental protocol involves the in-flow conversion of the carboxylic acid into <i>N-</i>acylpyrazole followed by the α-trifluoromethylthiolation in a PTFE coil reactor and final reaction with primary or secondary amines, or alcohols, to afford in a telescoped process α-substituted SCF₃ amides and esters, respectively, in good overall yield and short reaction times.2021-01-01T00:00:00Z2021 Oct2025-04-18T17:28:11.34Z2025-04-07T04:59:03.87ZS-EPMC85244183431458210.1021/acs.joc.1c01270