biostudies-literatureDel Rosario JNational Institutes of Health Neurological Disorders and StrokeSimons FoundationBLRD VAGeorgia Tech Neural Engineering CenterWhitehall FoundationRRD VANINDS NIH HHSNational Institutes of Health BRAIN InitiativeAlfred P. Sloan FoundationDepartment of Veterans Affairs Rehabilitation Research and Development Service Merit AwardGoizueta Foundation FellowshipResearch Career Scientist Award3462-3474https://www.ebi.ac.uk/biostudies/studies/S-EPMC8525192biostudies-literatureUnknown31(7)Sensory impairments are a core feature of autism spectrum disorder (ASD). These impairments affect visual perception and have been hypothesized to arise from imbalances in cortical excitatory and inhibitory activity. There is conflicting evidence for this hypothesis from several recent studies of transgenic mouse models of ASD; crucially, none have measured activity from identified excitatory and inhibitory neurons during simultaneous impairments of sensory perception. Here, we directly recorded putative excitatory and inhibitory population spiking in primary visual cortex (V1) while simultaneously measuring visual perceptual behavior in CNTNAP2-/- knockout (KO) mice. We observed quantitative impairments in the speed, accuracy, and contrast sensitivity of visual perception in KO mice. DuriCerebral cortex (New York, N.Y. : 1991)Diminished Cortical Excitation and Elevated Inhibition During Perceptual Impairments in a Mouse Model of Autism.PMC8525192R01 NS109978R01 NS107968NS1079681241384I01RX002615NS109978I01 BX002439I01 RX002615IK6 RX003134600343IK6RX003134Del Rosario JSpeed AArrowood HPardue MMotz CHaider BfalseDiminished Cortical Excitation and Elevated Inhibition During Perceptual Impairments in a Mouse Model of Autism.Sensory impairments are a core feature of autism spectrum disorder (ASD). These impairments affect visual perception and have been hypothesized to arise from imbalances in cortical excitatory and inhibitory activity. There is conflicting evidence for this hypothesis from several recent studies of transgenic mouse models of ASD; crucially, none have measured activity from identified excitatory and inhibitory neurons during simultaneous impairments of sensory perception. Here, we directly recorded putative excitatory and inhibitory population spiking in primary visual cortex (V1) while simultaneously measuring visual perceptual behavior in CNTNAP2-/- knockout (KO) mice. We observed quantitative impairments in the speed, accuracy, and contrast sensitivity of visual perception in KO mice. Duri2021-01-01T00:00:00Z2021 Jun2025-04-18T20:05:14.58Z2025-04-07T07:50:49.239ZS-EPMC85251923367751210.1093/cercor/bhab025