{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(17)"],"submitter":["Pena M"],"pubmed_abstract":["The Endothelial Activation and Stress Index (EASIX) is a laboratory-based prognosis index defined as creatinine × lactate dehydrogenase/platelets. When measured at pretransplantation evaluation (EASIX-PRE), it predicts allogeneic hematopoietic cell transplantation (alloHCT) mortality. This study explores its ability to predict intensive care unit (ICU) admission and validates EASIX-PRE predictive power for overall survival (OS) and nonrelapse mortality (NRM) in 167 consecutive patients undergoing alloHCT. EASIX-PRE was calculated retrospectively in all patients and transformed into log2 values (log2-EASIX-PRE). Log2-EASIX-PRE predicted ICU admission (hazard ratio [HR], 1.41; P < .001), OS (HR, 1.19; P = .011), and NRM (HR, 1.28; P = .004). The most discriminating EASIX-PRE cutoff value for"],"journal":["Blood advances"],"pagination":["3418-3426"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8525231"],"repository":["biostudies-literature"],"pubmed_title":["Pretransplantation EASIX predicts intensive care unit admission in allogeneic hematopoietic cell transplantation."],"pmcid":["PMC8525231"],"pubmed_authors":["Salas MQ","Sureda A","Pena M","Bosch A","Kara M","Jimenez L","Parody R","Moreno-Gonzalez G","Mussetti A","Patino B"],"additional_accession":[]},"is_claimable":false,"name":"Pretransplantation EASIX predicts intensive care unit admission in allogeneic hematopoietic cell transplantation.","description":"The Endothelial Activation and Stress Index (EASIX) is a laboratory-based prognosis index defined as creatinine × lactate dehydrogenase/platelets. When measured at pretransplantation evaluation (EASIX-PRE), it predicts allogeneic hematopoietic cell transplantation (alloHCT) mortality. This study explores its ability to predict intensive care unit (ICU) admission and validates EASIX-PRE predictive power for overall survival (OS) and nonrelapse mortality (NRM) in 167 consecutive patients undergoing alloHCT. EASIX-PRE was calculated retrospectively in all patients and transformed into log2 values (log2-EASIX-PRE). Log2-EASIX-PRE predicted ICU admission (hazard ratio [HR], 1.41; P < .001), OS (HR, 1.19; P = .011), and NRM (HR, 1.28; P = .004). The most discriminating EASIX-PRE cutoff value for","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-18T17:29:10.997Z","creation":"2025-04-07T04:59:14.592Z"},"accession":"S-EPMC8525231","cross_references":{"pubmed":["34495311"],"doi":["10.1182/bloodadvances.2021004812"]}}