biostudies-literatureUnknown5(17)Pena MThe Endothelial Activation and Stress Index (EASIX) is a laboratory-based prognosis index defined as creatinine × lactate dehydrogenase/platelets. When measured at pretransplantation evaluation (EASIX-PRE), it predicts allogeneic hematopoietic cell transplantation (alloHCT) mortality. This study explores its ability to predict intensive care unit (ICU) admission and validates EASIX-PRE predictive power for overall survival (OS) and nonrelapse mortality (NRM) in 167 consecutive patients undergoing alloHCT. EASIX-PRE was calculated retrospectively in all patients and transformed into log2 values (log2-EASIX-PRE). Log2-EASIX-PRE predicted ICU admission (hazard ratio [HR], 1.41; P < .001), OS (HR, 1.19; P = .011), and NRM (HR, 1.28; P = .004). The most discriminating EASIX-PRE cutoff value forBlood advances3418-3426https://www.ebi.ac.uk/biostudies/studies/S-EPMC8525231biostudies-literaturePretransplantation EASIX predicts intensive care unit admission in allogeneic hematopoietic cell transplantation.PMC8525231Salas MQSureda APena MBosch AKara MJimenez LParody RMoreno-Gonzalez GMussetti APatino BfalsePretransplantation EASIX predicts intensive care unit admission in allogeneic hematopoietic cell transplantation.The Endothelial Activation and Stress Index (EASIX) is a laboratory-based prognosis index defined as creatinine × lactate dehydrogenase/platelets. When measured at pretransplantation evaluation (EASIX-PRE), it predicts allogeneic hematopoietic cell transplantation (alloHCT) mortality. This study explores its ability to predict intensive care unit (ICU) admission and validates EASIX-PRE predictive power for overall survival (OS) and nonrelapse mortality (NRM) in 167 consecutive patients undergoing alloHCT. EASIX-PRE was calculated retrospectively in all patients and transformed into log2 values (log2-EASIX-PRE). Log2-EASIX-PRE predicted ICU admission (hazard ratio [HR], 1.41; P < .001), OS (HR, 1.19; P = .011), and NRM (HR, 1.28; P = .004). The most discriminating EASIX-PRE cutoff value for2021-01-01T00:00:00Z2021 Sep2025-04-18T17:29:10.997Z2025-04-07T04:59:14.592ZS-EPMC85252313449531110.1182/bloodadvances.2021004812