biostudies-literatureAlavi MVNational Institute of Allergy and Infectious DiseasesNIA NIH HHSNational Institutes of HealthNational Institute on Aging119116https://www.ebi.ac.uk/biostudies/studies/S-EPMC8525314biostudies-literatureUnknown1868(12)The neuropathological hallmarks of Alzheimer's Disease are plaques and neurofibrillary tangles. Yet, Alzheimer's is a complex disease with many contributing factors, such as energy-metabolic changes, which have been documented in autopsy brains from individuals with Alzheimer's and animal disease models alike. One conceivable explanation is that the interplay of age-related extracellular and intracellular alterations pertaining to Alzheimer's, such as cerebrovascular changes, protein aggregates and inflammation, evoke a mitochondrial response. However, it is not clear if and how mitochondria can contribute to Alzheimer's pathophysiology. This study focuses on one particular aspect of this question by investigating the functional interaction between the microtubule-associated protein tau anBiochimica et biophysica acta. Molecular cell researchTau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease.PMC8525314R43AG063642R43 AG063642Alavi MVfalseTau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease.The neuropathological hallmarks of Alzheimer's Disease are plaques and neurofibrillary tangles. Yet, Alzheimer's is a complex disease with many contributing factors, such as energy-metabolic changes, which have been documented in autopsy brains from individuals with Alzheimer's and animal disease models alike. One conceivable explanation is that the interplay of age-related extracellular and intracellular alterations pertaining to Alzheimer's, such as cerebrovascular changes, protein aggregates and inflammation, evoke a mitochondrial response. However, it is not clear if and how mitochondria can contribute to Alzheimer's pathophysiology. This study focuses on one particular aspect of this question by investigating the functional interaction between the microtubule-associated protein tau an2021-01-01T00:00:00Z2021 Nov2025-04-05T13:44:14.893Z2025-04-05T13:44:14.893ZS-EPMC85253143440017210.1016/j.bbamcr.2021.119116