{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gilchuk IM"],"funding":["NCATS NIH HHS","NIAID NIH HHS","NIH/NCATS","NIH/NIAID"],"pagination":["e152403"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8525637"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(19)"],"pubmed_abstract":["Avian H7N9 influenza viruses cause sporadic outbreaks of human infections and threaten to cause a major pandemic. The breadth of B cell responses to natural infection and the dominant antigenic sites recognized during first exposure to H7 HA following infection are incompletely understood. Here, we studied the B cell response to H7 HA of 2 individuals who had recovered from natural H7N9 virus infection. We used competition binding, hydrogen-deuterium mass spectrometry, and single-particle negative stain electron microscopy to identify the patterns of molecular recognition of the antibody responses to H7 HA. We found that circulating H7-reactive B cells recognized a diverse antigenic landscape on the HA molecule, including HA head domain epitopes in antigenic sites A and B and in the trimer"],"journal":["JCI insight"],"pubmed_title":["Human antibody recognition of H7N9 influenza virus HA following natural infection."],"pmcid":["PMC8525637"],"funding_grant_id":["UL1 TR002243","HHSN272201400024C","U01 AI150739"],"pubmed_authors":["Trivette A","Li S","Turner HL","Bombardi RG","Crowe JE","Kose N","Bangaru S","Ward AB","Gilchuk IM","Carnahan RH"],"additional_accession":[]},"is_claimable":false,"name":"Human antibody recognition of H7N9 influenza virus HA following natural infection.","description":"Avian H7N9 influenza viruses cause sporadic outbreaks of human infections and threaten to cause a major pandemic. The breadth of B cell responses to natural infection and the dominant antigenic sites recognized during first exposure to H7 HA following infection are incompletely understood. Here, we studied the B cell response to H7 HA of 2 individuals who had recovered from natural H7N9 virus infection. We used competition binding, hydrogen-deuterium mass spectrometry, and single-particle negative stain electron microscopy to identify the patterns of molecular recognition of the antibody responses to H7 HA. We found that circulating H7-reactive B cells recognized a diverse antigenic landscape on the HA molecule, including HA head domain epitopes in antigenic sites A and B and in the trimer","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2026-05-08T15:49:59.045Z","creation":"2025-02-19T00:03:07.305Z"},"accession":"S-EPMC8525637","cross_references":{"pubmed":["34437301"],"doi":["10.1172/jci.insight.152403"]}}