{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Song S"],"funding":["National Key R&amp;D Program of China"],"pagination":["5528780"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8526210"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2021"],"pubmed_abstract":["<h4>Background</h4>Manual acupuncture (MA) with different stimulus frequencies may give rise to varying acupuncture effects. However, the intensity-effect relationship and the underlying mechanisms of MA remain unclear.<h4>Objective</h4>To compare the analgesic effects of different frequencies of twirling-rotating MA on rats with complete Freund's adjuvant- (CFA-) induced pain and explore the underlying mechanism via peripheral sensory nerves.<h4>Methods</h4>First, 36 healthy male Wistar rats were randomly divided into 6 groups: control group, 2 r/s MA group (twirling-rotating MA with the frequency of 2 revolutions per second), 4 r/s MA group (twirling-rotating MA with the frequency of 4 revolutions per second), CFA group, CFA + 2 r/s MA group, and CFA + 4 r/s MA group. Rats in three CFA g"],"journal":["Evidence-based complementary and alternative medicine : eCAM"],"pubmed_title":["Strong Twirling-Rotating Manual Acupuncture with 4 r/s Is Superior to 2 r/s in Relieving Pain by Activating C-Fibers in Rat Models of CFA-Induced Pain."],"pmcid":["PMC8526210"],"funding_grant_id":["2019YFC1709003","17JCQNJC12200"],"pubmed_authors":["Liu Y","Liu J","Guo Y","Jia Y","Song S","Lin X","Wang H","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Strong Twirling-Rotating Manual Acupuncture with 4 r/s Is Superior to 2 r/s in Relieving Pain by Activating C-Fibers in Rat Models of CFA-Induced Pain.","description":"<h4>Background</h4>Manual acupuncture (MA) with different stimulus frequencies may give rise to varying acupuncture effects. However, the intensity-effect relationship and the underlying mechanisms of MA remain unclear.<h4>Objective</h4>To compare the analgesic effects of different frequencies of twirling-rotating MA on rats with complete Freund's adjuvant- (CFA-) induced pain and explore the underlying mechanism via peripheral sensory nerves.<h4>Methods</h4>First, 36 healthy male Wistar rats were randomly divided into 6 groups: control group, 2 r/s MA group (twirling-rotating MA with the frequency of 2 revolutions per second), 4 r/s MA group (twirling-rotating MA with the frequency of 4 revolutions per second), CFA group, CFA + 2 r/s MA group, and CFA + 4 r/s MA group. Rats in three CFA g","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-05-31T23:18:43.661Z","creation":"2025-05-31T23:18:43.661Z"},"accession":"S-EPMC8526210","cross_references":{"pubmed":["34675986"],"doi":["10.1155/2021/5528780"]}}