{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8"],"submitter":["Bichon A"],"pubmed_abstract":["<b>Background:</b> Adult hemophagocytic lymphohistiocytosis (HLH) is highly lethal in the ICU. The diagnostic and therapeutic emergency that HLH represents is compounded by its unknown pathophysiological mechanisms. Here, we report on a large cohort of adult HLH in the ICU (ICU-HLH). We analyzed prognostic factors associated with mortality to define the diagnostic and therapeutic challenges in this specific population. <b>Methods:</b> This retrospective study included adult patients diagnosed with HLH in four ICUs in Marseille, France between 2010 and 2020. Patients who fulfilled the HLH-2004 criteria (≥ 4/8) and/or had an HScore ≥ 169 were diagnosed with HLH. HLH was categorized into four groups according to etiology: sepsis-associated HLH, intracellular infection-associated HLH, malignan"],"journal":["Frontiers in medicine"],"pagination":["735796"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8526960"],"repository":["biostudies-literature"],"pubmed_title":["High Mortality of HLH in ICU Regardless Etiology or Treatment."],"pmcid":["PMC8526960"],"pubmed_authors":["Bourenne J","Bichon A","Kaplanski G","Gainnier M","Hraiech S","Carvelli J","Guervilly C","Pauly V","Allardet-Servent J","Papazian L","Mokart D"],"additional_accession":[]},"is_claimable":false,"name":"High Mortality of HLH in ICU Regardless Etiology or Treatment.","description":"<b>Background:</b> Adult hemophagocytic lymphohistiocytosis (HLH) is highly lethal in the ICU. The diagnostic and therapeutic emergency that HLH represents is compounded by its unknown pathophysiological mechanisms. Here, we report on a large cohort of adult HLH in the ICU (ICU-HLH). We analyzed prognostic factors associated with mortality to define the diagnostic and therapeutic challenges in this specific population. <b>Methods:</b> This retrospective study included adult patients diagnosed with HLH in four ICUs in Marseille, France between 2010 and 2020. Patients who fulfilled the HLH-2004 criteria (≥ 4/8) and/or had an HScore ≥ 169 were diagnosed with HLH. HLH was categorized into four groups according to etiology: sepsis-associated HLH, intracellular infection-associated HLH, malignan","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-07-16T15:59:09.683Z","creation":"2025-04-04T19:44:36.048Z"},"accession":"S-EPMC8526960","cross_references":{"pubmed":["34692727"],"doi":["10.3389/fmed.2021.735796"]}}