{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Quarta CC"],"funding":["British Heart Foundation","BHF Intermediate Clinical Research Fellowship"],"pagination":["1304-1311"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8527328"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(11)"],"pubmed_abstract":["Aims
Technetium-99m-labelled 3,3-diphosphono-1,2-propanodicarboxylic acid (99mTc-DPD scintigraphy) is recognized as highly accurate for the non-invasive diagnosis of transthyretin (ATTR) cardiac amyloidosis (CA). A proportion of patients with immunoglobulin light chain (AL) CA have also been reported to show cardiac 99mTc-DPD uptake. Herein, we assessed the frequency and degree of cardiac 99mTc-DPD uptake and its clinical significance among patients with AL CA.Methods and results
Between 2010 and 2017, 292 consecutive patients with AL CA underwent 99mTc-DPD scintigraphy and were included in this study: 114 (39%) had cardiac 99mTc-DPD uptake: grade 1 in 75%, grade 2 in 17%, and grade 3 in 8% of cases. Patients with cardiac 99mTc-DPD uptake had poorer cardiac systolic functio"],"journal":["European heart journal. Cardiovascular Imaging"],"pubmed_title":["99mTc-DPD scintigraphy in immunoglobulin light chain (AL) cardiac amyloidosis."],"pmcid":["PMC8527328"],"funding_grant_id":["FS/18/21/33447"],"pubmed_authors":["Manwani R","Whelan CJ","Wechalekar AD","Grigore SF","Rapezzi C","Lachmann HJ","Fontana M","Zheng J","Hawkins PN","Martinez-Naharro A","Gillmore JD","Hutt D","Chacko L","Sachchithanantham S","Mahmood SA","Quarta CC"],"additional_accession":[]},"is_claimable":false,"name":"99mTc-DPD scintigraphy in immunoglobulin light chain (AL) cardiac amyloidosis.","description":"Aims
Technetium-99m-labelled 3,3-diphosphono-1,2-propanodicarboxylic acid (99mTc-DPD scintigraphy) is recognized as highly accurate for the non-invasive diagnosis of transthyretin (ATTR) cardiac amyloidosis (CA). A proportion of patients with immunoglobulin light chain (AL) CA have also been reported to show cardiac 99mTc-DPD uptake. Herein, we assessed the frequency and degree of cardiac 99mTc-DPD uptake and its clinical significance among patients with AL CA.Methods and results
Between 2010 and 2017, 292 consecutive patients with AL CA underwent 99mTc-DPD scintigraphy and were included in this study: 114 (39%) had cardiac 99mTc-DPD uptake: grade 1 in 75%, grade 2 in 17%, and grade 3 in 8% of cases. Patients with cardiac 99mTc-DPD uptake had poorer cardiac systolic functio","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-19T15:10:45.984Z","creation":"2025-04-19T15:10:45.984Z"},"accession":"S-EPMC8527328","cross_references":{"pubmed":["34254119"],"doi":["10.1093/ehjci/jeab095"]}}