biostudies-literatureProietti MBoston Scientific CorporationEdwards LifesciencesFondazione Internazionale MenariniAmgen CardiovascularVifor PharmaNovartis PharmaBayerGedeon RichterThe Alliance Daiichi Sankyo Europe GmbH and Eli Lilly and CompanyBoehringer IngelheimNational Institute for Health Research (NIHR)The Bristol Myers Squibb and Pfizer AllianceAstraZenecaServierMSD-Merck &amp; Co.Abbott VascularSanofiResMed256https://www.ebi.ac.uk/biostudies/studies/S-EPMC8527730biostudies-literatureUnknown19(1)<h4>Background</h4>Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients' clinical phenotypes and analyse the differential clinical course.<h4>Methods</h4>We performed a hierarchical cluster analysis based on Ward's Method and Squared Euclidean Distance using 22 clinical binary variables, identifying the optimal number of clusters. We investigated differences in clinical management, use of healthcare resources and outcomes in a cohort of European AF patients from a Europe-wide observational registry.<h4>Results</h4>A total of 9363 were available for this analysis. We identified three clusters: Cluster 1 (n = 3634; 38.8%) characterized by older patients and prevalent non-BMC medicineImpact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry.PMC8527730NIHR201320Loehndorf SMetherell SAllison JAbalea JOzieranski KNabauer MLane DTaieb JDi Chiara AWinstanley LMartel IJan ADoncovska SEsen EErglis ARitter OReithmeier ALe Heuzey JIlic SFletcher LIlic VStreb WRiabaia IRussell KStarflinger AZajac PSliwinski APolat NBerger MStockport JRautureau JBairamukova ASerdechnaya EGrundt JAnguita MEkmekciu USvenningsen APetkar SBenham LHoward LSantos JHettwer SSantos LVonderhagen EJedrzejczyk-Patej EKuppens CPescariu SBelcher GMay OStarling JBaumer AFauchier LDaniela RDechering DCordeiro ATonks LXuereb RMishra BStenzel GDurak Mvan Eck MFeatherstone JDupuis JLipski PMazurek MMills CMills HSaunders GBrophy KJacob PWilde 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HPearson JPopovic ZMartens EToprak NVassaliere CTokgozoglu LGelev VTyminska AMcDonald JPetroska KStasiak MDayer MDayal NGonzalez Juanatey JBalsam PEvans LStevanovic ASander CLeao SShutova JJanion MShalganov TLange IMirone PMarni Joensen ALivingstone CMarchov DLeperchois-Jacquey CKaba RJhagra OAdamczewski JIric-Cupic VTjuleneva LSekularac NDemir MHimbert CLeopold-Jadczyk ARusanova GKidd SBiedron MNatelashvili NElbaz NPeller MJensen LKolodziej MSus IRichter JLe Bidan MBoyer MESC-EHRA EORP-AF Long-Term General Registry InvestigatorsStumm RKerimkulova AGorczyca-Michta IMornos CKrysiak WO'Donohoe LZoccali CAndric ABrunello IStancheva NEngset IMiranda RMartignani CHordynski GDormal FBell LMaggioni APTase MRennie KTaggu WSlowikowski AReid LBartos DAcimovic TZera ELivia MReith RRice PLane DAKlaus CMairesse GLefevre MDyduch-Fejklowicz BPanagopoulos VGoanta EHughes DVukmirovic MNistor DYilmaz MBLoughlin AKeenan SBallesteros GDe Coninck MBoard SCottam VAlina-Ramona NStepien MBeveridge MStoicescu CMenabde IHassler NMirrakhimov ERunnett CMaupain CKuridze NTuckis LFechner SVan Opstal JNedeljkovic MCelic VPedley LBurg MGetty ABernardo RAndrews NSaul VSagirashvili ELeparree SBarth ATurcin Halka VPapiashvili GHarman ECotterill DAdams CKelsall NHolland MSoldatova ILazarova EJordanova SZycinski PBrockway LAdams MJovevska SAdams LGreenwood EMarin FSzymanska MTor RPetrescu LAhmad SRange GKoshum-Bayeva KKorinth APeric VSinha MPartridge JPavlovic NBrady RPavlovic MDuthoit GDarabantiu DThorpe KKoster SGil Ortega MRahman ILip GYHHaeussler-Schuchardt MDjouadi KKriete MDabrowski RSavovic ZMansourati JUmaar SFoth KSachse JMorka JKayapinar OBlicharz JFontes PHoskamp JMesser SKasprzak JMajos EBoni SCiurus TPetrykowska KHotz HZiacchi MPitt-Kerby TKuhlmann MfalseImpact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry.<h4>Background</h4>Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients' clinical phenotypes and analyse the differential clinical course.<h4>Methods</h4>We performed a hierarchical cluster analysis based on Ward's Method and Squared Euclidean Distance using 22 clinical binary variables, identifying the optimal number of clusters. We investigated differences in clinical management, use of healthcare resources and outcomes in a cohort of European AF patients from a Europe-wide observational registry.<h4>Results</h4>A total of 9363 were available for this analysis. We identified three clusters: Cluster 1 (n = 3634; 38.8%) characterized by older patients and prevalent non-2021-01-01T00:00:00Z2021 Oct2025-04-19T15:10:01.949Z2025-04-19T15:10:01.949ZS-EPMC85277303466675710.1186/s12916-021-02120-3