biostudies-literatureLiu APHealth and Medical Research FundFood and Health Bureau of the Government of the Hong Kong Special Administrative Regionvdab134https://www.ebi.ac.uk/biostudies/studies/S-EPMC8528264biostudies-literatureUnknown3(1)<h4>Background</h4>Medulloblastoma (MB) is the most common malignant central nervous system tumor of childhood. Management requires interdisciplinary care and is associated with unique challenges in developing regions. Here, we report the characteristics, clinical outcome and treatment barriers for Chinese children with MB based on a multi-institutional cohort from the Chinese Children's Cancer Group (CCCG).<h4>Methods</h4>Retrospective cohort study among 12 Chinese pediatric oncology units from the CCCG Brain Tumor Workgroup on patients aged <18 years diagnosed with MB from 2016 to 2019.<h4>Results</h4>221 patients (male:female = 138:83) were included, 175 (79%) were ≥3 years of age, and 46 (21%) <3 years. 177 patients (80%) were completely staged, among which 50 (28%) had metastasis and Neuro-oncology advancesTreatment barriers and clinical outcome of children with medulloblastoma in China: a report from the Chinese Children's Cancer Group (CCCG).PMC852826406171666Yu LJiang LMa XChan GCGe MHuang LZhen ZJiang MWang JLiu WHo WWNg HKGuo HWu SYuan XYang LLi CChen JWeng WHe KCheng KKSun XZeng JLiu APYang QZhu SfalseTreatment barriers and clinical outcome of children with medulloblastoma in China: a report from the Chinese Children's Cancer Group (CCCG).<h4>Background</h4>Medulloblastoma (MB) is the most common malignant central nervous system tumor of childhood. Management requires interdisciplinary care and is associated with unique challenges in developing regions. Here, we report the characteristics, clinical outcome and treatment barriers for Chinese children with MB based on a multi-institutional cohort from the Chinese Children's Cancer Group (CCCG).<h4>Methods</h4>Retrospective cohort study among 12 Chinese pediatric oncology units from the CCCG Brain Tumor Workgroup on patients aged <18 years diagnosed with MB from 2016 to 2019.<h4>Results</h4>221 patients (male:female = 138:83) were included, 175 (79%) were ≥3 years of age, and 46 (21%) <3 years. 177 patients (80%) were completely staged, among which 50 (28%) had metastasis and 2021-01-01T00:00:00Z2021 Jan-Dec2025-04-18T12:19:45.004Z2024-12-03T20:05:36.11ZS-EPMC85282643469328610.1093/noajnl/vdab134