{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(10)"],"submitter":["Koopmans SJ"],"funding":["The Ministry of Agriculture","Nature and Food Quality","Senter-Novem of The Netherlands"],"pubmed_abstract":["Background
Lifestyle influences endocrine, metabolic and cardiovascular homeostasis. This study investigated the impact of diet and oral anti-diabetic medication on cardio-metabolic health in human-sized diabetic pigs.Methods
After a growing pre-phase from ~30 to ~69 kg during which domestic pigs were fed either a low fat, low sucrose diet (group A) or a fast food-type diet elevated in lard (15%) and sucrose (40%) (group B), the pigs were subdivided in 5 groups (n = 7-8 pigs per group). Group 1, normal pigs from group A on a low fat, low sugar (L) pig diet and group 2, normal pigs from group B on a high lard (25%), sucrose-fructose (40%), cholesterol (1%) fast food-type (F) diet. Diabetes (D) was induced in group B pigs by streptozotocin and group 3 received the F diet (DF)"],"journal":["PloS one"],"pagination":["e0257299"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8528510"],"repository":["biostudies-literature"],"pubmed_title":["Beneficial effects of a plant-fish oil, slow carbohydrate diet on cardio-metabolic health exceed the correcting effects of metformin-pioglitazone in diabetic pigs fed a fast-food diet."],"pmcid":["PMC8528510"],"pubmed_authors":["Koopmans SJ","Hulst M","Mroz Z","van Beusekom HMM","Benthem L","Ackermans MT","van der Staay FJ","Binnendijk G"],"additional_accession":[]},"is_claimable":false,"name":"Beneficial effects of a plant-fish oil, slow carbohydrate diet on cardio-metabolic health exceed the correcting effects of metformin-pioglitazone in diabetic pigs fed a fast-food diet.","description":"Background
Lifestyle influences endocrine, metabolic and cardiovascular homeostasis. This study investigated the impact of diet and oral anti-diabetic medication on cardio-metabolic health in human-sized diabetic pigs.Methods
After a growing pre-phase from ~30 to ~69 kg during which domestic pigs were fed either a low fat, low sucrose diet (group A) or a fast food-type diet elevated in lard (15%) and sucrose (40%) (group B), the pigs were subdivided in 5 groups (n = 7-8 pigs per group). Group 1, normal pigs from group A on a low fat, low sugar (L) pig diet and group 2, normal pigs from group B on a high lard (25%), sucrose-fructose (40%), cholesterol (1%) fast food-type (F) diet. Diabetes (D) was induced in group B pigs by streptozotocin and group 3 received the F diet (DF)","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-08-28T03:09:04.782Z","creation":"2024-10-16T19:02:46.55Z"},"accession":"S-EPMC8528510","cross_references":{"pubmed":["34669714"],"doi":["10.1371/journal.pone.0257299"]}}