{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ahamad N"],"funding":["U.S. Department of Health &amp; Human Services | NIH | National Institute of Dental and Craniofacial Research","U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR)"],"pagination":["67"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8528841"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(1)"],"pubmed_abstract":["Stem cells have indefinite self-renewable capability; however, factors that modulate their pluripotency/function are not fully identified. Here we show that store-dependent Ca<sup>2+</sup> entry is essential for modulating the function of bone marrow-derived mesenchymal stem cells (MSCs). Increasing external Ca<sup>2+</sup> modulated cell cycle progression that was critical for MSCs survival. Additionally, Ca<sup>2+</sup> was critical for stem proliferation, its differentiation, and maintaining stem cell potential. Ca<sup>2+</sup> channel characterization, including gene silencing, showed two distinct Ca<sup>2+</sup> entry channels (through Orai1/TRPC1 or via Orai3) that differentially regulate the proliferation and viability of MSCs. Importantly, NFκB translocation, but not JNK/ERK into t"],"journal":["NPJ Regenerative medicine"],"pubmed_title":["Differential activation of Ca<sup>2+</sup> influx channels modulate stem cell potency, their proliferation/viability and tissue regeneration."],"pmcid":["PMC8528841"],"funding_grant_id":["R01DE017102","R21DE028265"],"pubmed_authors":["Xavier Paul Ezhilan CRD","Nascimento Da Conceicao V","Natarajan M","Singh BB","Ahamad N","Sun Y"],"additional_accession":[]},"is_claimable":false,"name":"Differential activation of Ca<sup>2+</sup> influx channels modulate stem cell potency, their proliferation/viability and tissue regeneration.","description":"Stem cells have indefinite self-renewable capability; however, factors that modulate their pluripotency/function are not fully identified. Here we show that store-dependent Ca<sup>2+</sup> entry is essential for modulating the function of bone marrow-derived mesenchymal stem cells (MSCs). Increasing external Ca<sup>2+</sup> modulated cell cycle progression that was critical for MSCs survival. Additionally, Ca<sup>2+</sup> was critical for stem proliferation, its differentiation, and maintaining stem cell potential. Ca<sup>2+</sup> channel characterization, including gene silencing, showed two distinct Ca<sup>2+</sup> entry channels (through Orai1/TRPC1 or via Orai3) that differentially regulate the proliferation and viability of MSCs. Importantly, NFκB translocation, but not JNK/ERK into t","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-19T15:09:42.986Z","creation":"2025-02-19T00:18:36.892Z"},"accession":"S-EPMC8528841","cross_references":{"pubmed":["34671058"],"doi":["10.1038/s41536-021-00180-w"]}}