{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Chowdhury A"],"funding":["Australian Research Council"],"pubmed_abstract":["African spitting cobras are unique among cobras for their potent anticoagulant venom activity arising from strong inhibition of Factor Xa. This anticoagulant effect is exerted by venom phospholipase A<sub>2</sub> (Group I PLA<sub>2</sub>) toxins whose activity contributes to the lethality of these species. This anticoagulant toxicity is particularly problematic as it is not neutralized by current antivenoms. Previous work demonstrated this trait for <i>Naja mossambica, N. nigricincta</i>, <i>N. nigricollis</i>, and <i>N. pallida.</i> The present work builds upon previous research by testing across the full taxonomical range of African spitting cobras, demonstrating that <i>N. ashei</i>, <i>N. katiensis</i>, and <i>N. nubiae</i> are also potently anticoagulant through the inhibition of Fact"],"journal":["Frontiers in immunology"],"pagination":["752442"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8529177"],"repository":["biostudies-literature"],"pubmed_title":["The Relative Efficacy of Chemically Diverse Small-Molecule Enzyme-Inhibitors Against Anticoagulant Activities of African Spitting Cobra (<i>Naja</i> Species) Venoms."],"pmcid":["PMC8529177"],"pubmed_authors":["Fry BG","Chowdhury A","Carter R","Lewin MR","Zdenek CN"],"additional_accession":[]},"is_claimable":false,"name":"The Relative Efficacy of Chemically Diverse Small-Molecule Enzyme-Inhibitors Against Anticoagulant Activities of African Spitting Cobra (<i>Naja</i> Species) Venoms.","description":"African spitting cobras are unique among cobras for their potent anticoagulant venom activity arising from strong inhibition of Factor Xa. This anticoagulant effect is exerted by venom phospholipase A<sub>2</sub> (Group I PLA<sub>2</sub>) toxins whose activity contributes to the lethality of these species. This anticoagulant toxicity is particularly problematic as it is not neutralized by current antivenoms. Previous work demonstrated this trait for <i>Naja mossambica, N. nigricincta</i>, <i>N. nigricollis</i>, and <i>N. pallida.</i> The present work builds upon previous research by testing across the full taxonomical range of African spitting cobras, demonstrating that <i>N. ashei</i>, <i>N. katiensis</i>, and <i>N. nubiae</i> are also potently anticoagulant through the inhibition of Fact","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-20T02:04:44.418Z","creation":"2025-04-20T02:04:44.418Z"},"accession":"S-EPMC8529177","cross_references":{"pubmed":["34691069"],"doi":["10.3389/fimmu.2021.752442"]}}