biostudies-literatureUnknown12Chowdhury AAustralian Research CouncilAfrican spitting cobras are unique among cobras for their potent anticoagulant venom activity arising from strong inhibition of Factor Xa. This anticoagulant effect is exerted by venom phospholipase A₂ (Group I PLA₂) toxins whose activity contributes to the lethality of these species. This anticoagulant toxicity is particularly problematic as it is not neutralized by current antivenoms. Previous work demonstrated this trait for <i>Naja mossambica, N. nigricincta</i>, <i>N. nigricollis</i>, and <i>N. pallida.</i> The present work builds upon previous research by testing across the full taxonomical range of African spitting cobras, demonstrating that <i>N. ashei</i>, <i>N. katiensis</i>, and <i>N. nubiae</i> are also potently anticoagulant through the inhibition of FactFrontiers in immunology752442https://www.ebi.ac.uk/biostudies/studies/S-EPMC8529177biostudies-literatureThe Relative Efficacy of Chemically Diverse Small-Molecule Enzyme-Inhibitors Against Anticoagulant Activities of African Spitting Cobra (<i>Naja</i> Species) Venoms.PMC8529177Fry BGChowdhury ACarter RLewin MRZdenek CNfalseThe Relative Efficacy of Chemically Diverse Small-Molecule Enzyme-Inhibitors Against Anticoagulant Activities of African Spitting Cobra (<i>Naja</i> Species) Venoms.African spitting cobras are unique among cobras for their potent anticoagulant venom activity arising from strong inhibition of Factor Xa. This anticoagulant effect is exerted by venom phospholipase A₂ (Group I PLA₂) toxins whose activity contributes to the lethality of these species. This anticoagulant toxicity is particularly problematic as it is not neutralized by current antivenoms. Previous work demonstrated this trait for <i>Naja mossambica, N. nigricincta</i>, <i>N. nigricollis</i>, and <i>N. pallida.</i> The present work builds upon previous research by testing across the full taxonomical range of African spitting cobras, demonstrating that <i>N. ashei</i>, <i>N. katiensis</i>, and <i>N. nubiae</i> are also potently anticoagulant through the inhibition of Fact2021-01-01T00:00:00Z20212025-04-20T02:04:44.418Z2025-04-20T02:04:44.418ZS-EPMC85291773469106910.3389/fimmu.2021.752442