{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["162(2)"],"submitter":["Zhang F"],"funding":["Government of the Hong Kong Special Administrative Region of the People"],"pubmed_abstract":["<h4>Background and aims</h4>Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with altered gut microbiota composition. Phylogenetic groups of gut bacteria involved in the metabolism of short chain fatty acids (SCFAs) were depleted in SARS-CoV-2-infected patients. We aimed to characterize a functional profile of the gut microbiome in patients with COVID-19 before and after disease resolution.<h4>Methods</h4>We performed shotgun metagenomic sequencing on fecal samples from 66 antibiotics-naïve patients with COVID-19 and 70 non-COVID-19 controls. Serial fecal samples were collected (at up to 6 times points) during hospitalization and beyond 1 month after discharge. We assessed gut microbial pathways in associatio"],"journal":["Gastroenterology"],"pagination":["548-561.e4"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8529231"],"repository":["biostudies-literature"],"pubmed_title":["Prolonged Impairment of Short-Chain Fatty Acid and L-Isoleucine Biosynthesis in Gut Microbiome in Patients With COVID-19."],"pmcid":["PMC8529231"],"pubmed_authors":["Zhang F","Cheung CP","Zuo T","Chan FKL","Lu W","Liu Q","Wan Y","Lui GCY","Zhang L","Ng SC","Chan PKS","Wong CK","Li AYL","Zhan H","Yeoh YK","Xu W"],"additional_accession":[]},"is_claimable":false,"name":"Prolonged Impairment of Short-Chain Fatty Acid and L-Isoleucine Biosynthesis in Gut Microbiome in Patients With COVID-19.","description":"<h4>Background and aims</h4>Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with altered gut microbiota composition. Phylogenetic groups of gut bacteria involved in the metabolism of short chain fatty acids (SCFAs) were depleted in SARS-CoV-2-infected patients. We aimed to characterize a functional profile of the gut microbiome in patients with COVID-19 before and after disease resolution.<h4>Methods</h4>We performed shotgun metagenomic sequencing on fecal samples from 66 antibiotics-naïve patients with COVID-19 and 70 non-COVID-19 controls. Serial fecal samples were collected (at up to 6 times points) during hospitalization and beyond 1 month after discharge. We assessed gut microbial pathways in associatio","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2026-04-08T07:38:36.311Z","creation":"2022-02-11T16:15:54.45Z"},"accession":"S-EPMC8529231","cross_references":{"pubmed":["34687739"],"doi":["10.1053/j.gastro.2021.10.013"]}}