biostudies-literatureUnknown162(2)Zhang FGovernment of the Hong Kong Special Administrative Region of the People<h4>Background and aims</h4>Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with altered gut microbiota composition. Phylogenetic groups of gut bacteria involved in the metabolism of short chain fatty acids (SCFAs) were depleted in SARS-CoV-2-infected patients. We aimed to characterize a functional profile of the gut microbiome in patients with COVID-19 before and after disease resolution.<h4>Methods</h4>We performed shotgun metagenomic sequencing on fecal samples from 66 antibiotics-naïve patients with COVID-19 and 70 non-COVID-19 controls. Serial fecal samples were collected (at up to 6 times points) during hospitalization and beyond 1 month after discharge. We assessed gut microbial pathways in associatioGastroenterology548-561.e4https://www.ebi.ac.uk/biostudies/studies/S-EPMC8529231biostudies-literatureProlonged Impairment of Short-Chain Fatty Acid and L-Isoleucine Biosynthesis in Gut Microbiome in Patients With COVID-19.PMC8529231Zhang FCheung CPZuo TChan FKLLu WLiu QWan YLui GCYZhang LNg SCChan PKSWong CKLi AYLZhan HYeoh YKXu WfalseProlonged Impairment of Short-Chain Fatty Acid and L-Isoleucine Biosynthesis in Gut Microbiome in Patients With COVID-19.<h4>Background and aims</h4>Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with altered gut microbiota composition. Phylogenetic groups of gut bacteria involved in the metabolism of short chain fatty acids (SCFAs) were depleted in SARS-CoV-2-infected patients. We aimed to characterize a functional profile of the gut microbiome in patients with COVID-19 before and after disease resolution.<h4>Methods</h4>We performed shotgun metagenomic sequencing on fecal samples from 66 antibiotics-naïve patients with COVID-19 and 70 non-COVID-19 controls. Serial fecal samples were collected (at up to 6 times points) during hospitalization and beyond 1 month after discharge. We assessed gut microbial pathways in associatio2022-01-01T00:00:00Z2022 Feb2026-04-08T07:38:36.311Z2022-02-11T16:15:54.45ZS-EPMC85292313468773910.1053/j.gastro.2021.10.013