{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chou RH"],"funding":["ministry of health and welfare","taipei veterans general hospital","ministry of science and technology, taiwan"],"pagination":["65"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8529374"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["Background
Trimethylamine N-oxide (TMAO) is a microbiota-derived metabolite, which is linked to vascular inflammation and atherosclerosis in cardiovascular (CV) diseases. But its effect in infectious diseases remains unclear. We conducted a single-center prospective study to investigate association of TMAO with in-hospital mortality in septic patients admitted to an intensive care unit (ICU).Methods
Totally 95 septic, mechanically ventilated patients were enrolled. Blood samples were obtained within 24 h after ICU admission, and plasma TMAO concentrations were determined. Septic patients were grouped into tertiles according to TMAO concentration. The primary outcome was in-hospital death, which further classified as CV and non-CV death. Besides, we also compared the TMAO co"],"journal":["Journal of intensive care"],"pubmed_title":["Paradox of trimethylamine-N-oxide, the impact of malnutrition on microbiota-derived metabolites and septic patients."],"pmcid":["PMC8529374"],"funding_grant_id":["MOST 106-2314-B-350-001-MY3","V109D50-003-MY3-1","V108C-195","V105C-207","MOHW106-TDU-B-211-113001","V106C-045","V109B-010"],"pubmed_authors":["Chou RH","Tsai YL","Guo JY","Lien RY","Wang SC","Lin SJ","Lu SF","Lu YW","Chou RY","Wu CH","Wu PS","Huang PH","Kuo MR"],"additional_accession":[]},"is_claimable":false,"name":"Paradox of trimethylamine-N-oxide, the impact of malnutrition on microbiota-derived metabolites and septic patients.","description":"Background
Trimethylamine N-oxide (TMAO) is a microbiota-derived metabolite, which is linked to vascular inflammation and atherosclerosis in cardiovascular (CV) diseases. But its effect in infectious diseases remains unclear. We conducted a single-center prospective study to investigate association of TMAO with in-hospital mortality in septic patients admitted to an intensive care unit (ICU).Methods
Totally 95 septic, mechanically ventilated patients were enrolled. Blood samples were obtained within 24 h after ICU admission, and plasma TMAO concentrations were determined. Septic patients were grouped into tertiles according to TMAO concentration. The primary outcome was in-hospital death, which further classified as CV and non-CV death. Besides, we also compared the TMAO co","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-18T13:44:19.79Z","creation":"2025-02-18T23:27:45.461Z"},"accession":"S-EPMC8529374","cross_references":{"pubmed":["34674768"],"doi":["10.1186/s40560-021-00581-5"]}}