biostudies-literatureChou RHministry of health and welfaretaipei veterans general hospitalministry of science and technology, taiwan65https://www.ebi.ac.uk/biostudies/studies/S-EPMC8529374biostudies-literatureUnknown9(1)<h4>Background</h4>Trimethylamine N-oxide (TMAO) is a microbiota-derived metabolite, which is linked to vascular inflammation and atherosclerosis in cardiovascular (CV) diseases. But its effect in infectious diseases remains unclear. We conducted a single-center prospective study to investigate association of TMAO with in-hospital mortality in septic patients admitted to an intensive care unit (ICU).<h4>Methods</h4>Totally 95 septic, mechanically ventilated patients were enrolled. Blood samples were obtained within 24 h after ICU admission, and plasma TMAO concentrations were determined. Septic patients were grouped into tertiles according to TMAO concentration. The primary outcome was in-hospital death, which further classified as CV and non-CV death. Besides, we also compared the TMAO coJournal of intensive careParadox of trimethylamine-N-oxide, the impact of malnutrition on microbiota-derived metabolites and septic patients.PMC8529374MOST 106-2314-B-350-001-MY3V109D50-003-MY3-1V108C-195V105C-207MOHW106-TDU-B-211-113001V106C-045V109B-010Chou RHTsai YLGuo JYLien RYWang SCLin SJLu SFLu YWChou RYWu CHWu PSHuang PHKuo MRfalseParadox of trimethylamine-N-oxide, the impact of malnutrition on microbiota-derived metabolites and septic patients.<h4>Background</h4>Trimethylamine N-oxide (TMAO) is a microbiota-derived metabolite, which is linked to vascular inflammation and atherosclerosis in cardiovascular (CV) diseases. But its effect in infectious diseases remains unclear. We conducted a single-center prospective study to investigate association of TMAO with in-hospital mortality in septic patients admitted to an intensive care unit (ICU).<h4>Methods</h4>Totally 95 septic, mechanically ventilated patients were enrolled. Blood samples were obtained within 24 h after ICU admission, and plasma TMAO concentrations were determined. Septic patients were grouped into tertiles according to TMAO concentration. The primary outcome was in-hospital death, which further classified as CV and non-CV death. Besides, we also compared the TMAO co2021-01-01T00:00:00Z2021 Oct2025-04-18T13:44:19.79Z2025-02-18T23:27:45.461ZS-EPMC85293743467476810.1186/s40560-021-00581-5