{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Amiri P"],"funding":["Roger's family and Open Philanthropy Award, and Keck Start-Up Funding","NHLBI NIH HHS","National Institutes of Health","NIH HHS"],"pagination":["e2101912"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8529433"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(20)"],"pubmed_abstract":["Blood exchanges between young and old partners demonstrate old blood has a detrimental effect on brain health of young animals. Previous studies primarily investigate soluble blood factors, such as transforming growth factor-beta, on the brain and the blood-brain barrier (BBB). However, the role of blood cellular components, particularly erythrocytes, has not been defined. Erythrocyte morphology and rigidity change as mammals age, altering their transport within the capillary bed. This impacts downstream biological events, such as the release of reactive oxygen species and hemoglobin, potentially compromising the BBB. Here, a micro electrical BBB (µE-BBB), with cocultured endothelial and astrocytic cells, and a built-in trans-endothelial electrical resistance (TEER) system is described to "],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Erythrocytes, a New Contributor to Age-Associated Loss of Blood-Brain Barrier Integrity."],"pmcid":["PMC8529433"],"funding_grant_id":["R01 HL139605‐01","R01 HL139605-01","GR700029RDA","R01 HL139605"],"pubmed_authors":["Lu HW","Conboy I","DeCastro J","Amiri P","Aran K","Littig J","Liu C"],"additional_accession":[]},"is_claimable":false,"name":"Erythrocytes, a New Contributor to Age-Associated Loss of Blood-Brain Barrier Integrity.","description":"Blood exchanges between young and old partners demonstrate old blood has a detrimental effect on brain health of young animals. Previous studies primarily investigate soluble blood factors, such as transforming growth factor-beta, on the brain and the blood-brain barrier (BBB). However, the role of blood cellular components, particularly erythrocytes, has not been defined. Erythrocyte morphology and rigidity change as mammals age, altering their transport within the capillary bed. This impacts downstream biological events, such as the release of reactive oxygen species and hemoglobin, potentially compromising the BBB. Here, a micro electrical BBB (µE-BBB), with cocultured endothelial and astrocytic cells, and a built-in trans-endothelial electrical resistance (TEER) system is described to ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2026-06-02T18:30:08.856Z","creation":"2025-02-18T23:55:42.369Z"},"accession":"S-EPMC8529433","cross_references":{"pubmed":["34396716"],"doi":["10.1002/advs.202101912"]}}