{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Siu YM"],"funding":["Welch Foundation","National Institute of General Medical Sciences","NIGMS NIH HHS","NIH HHS"],"pagination":["10590-10595"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8529965"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["143(28)"],"pubmed_abstract":["The total synthesis of leiodermatolide A was accomplished in 13 steps (LLS). Transfer hydrogenative variants of three carbonyl additions that traditionally rely on premetalated reagents (allylation, crotylation, and propargylation) are deployed together in one total synthesis."],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Total Synthesis of Leiodermatolide A via Transfer Hydrogenative Allylation, Crotylation, and Propargylation: Polyketide Construction beyond Discrete Allyl- or Allenylmetal Reagents."],"pmcid":["PMC8529965"],"funding_grant_id":["S10 OD021508","R01 GM093905","F-0038"],"pubmed_authors":["Krische MJ","Roane J","Siu YM"],"additional_accession":[]},"is_claimable":false,"name":"Total Synthesis of Leiodermatolide A via Transfer Hydrogenative Allylation, Crotylation, and Propargylation: Polyketide Construction beyond Discrete Allyl- or Allenylmetal Reagents.","description":"The total synthesis of leiodermatolide A was accomplished in 13 steps (LLS). Transfer hydrogenative variants of three carbonyl additions that traditionally rely on premetalated reagents (allylation, crotylation, and propargylation) are deployed together in one total synthesis.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2025-04-22T09:19:26.64Z","creation":"2025-04-05T22:59:03.12Z"},"accession":"S-EPMC8529965","cross_references":{"pubmed":["34237219"],"doi":["10.1021/jacs.1c06062"]}}