biostudies-literatureSiu YMWelch FoundationNational Institute of General Medical SciencesNIGMS NIH HHSNIH HHS10590-10595https://www.ebi.ac.uk/biostudies/studies/S-EPMC8529965biostudies-literatureUnknown143(28)The total synthesis of leiodermatolide A was accomplished in 13 steps (LLS). Transfer hydrogenative variants of three carbonyl additions that traditionally rely on premetalated reagents (allylation, crotylation, and propargylation) are deployed together in one total synthesis.Journal of the American Chemical SocietyTotal Synthesis of Leiodermatolide A via Transfer Hydrogenative Allylation, Crotylation, and Propargylation: Polyketide Construction beyond Discrete Allyl- or Allenylmetal Reagents.PMC8529965S10 OD021508R01 GM093905F-0038Krische MJRoane JSiu YMfalseTotal Synthesis of Leiodermatolide A via Transfer Hydrogenative Allylation, Crotylation, and Propargylation: Polyketide Construction beyond Discrete Allyl- or Allenylmetal Reagents.The total synthesis of leiodermatolide A was accomplished in 13 steps (LLS). Transfer hydrogenative variants of three carbonyl additions that traditionally rely on premetalated reagents (allylation, crotylation, and propargylation) are deployed together in one total synthesis.2021-01-01T00:00:00Z2021 Jul2025-04-22T09:19:26.64Z2025-04-05T22:59:03.12ZS-EPMC85299653423721910.1021/jacs.1c06062