biostudies-literatureGuimond SNCATS NIH HHSEmerging Research Innovators in Mental HealthNIMH NIH HHSNational Institute of Mental HealthFonds de recherche du Québec – Santé1706-1717https://www.ebi.ac.uk/biostudies/studies/S-EPMC8530385biostudies-literatureUnknown47(6)<h4>Objective</h4>Brain-based Biotypes for psychotic disorders have been developed as part of the B-SNIP consortium to create neurobiologically distinct subgroups within idiopathic psychosis, independent from traditional phenomenological diagnostic methods. In the current study, we aimed to validate the Biotype model by assessing differences in volume and shape of the amygdala and hippocampus contrasting traditional clinical diagnoses with Biotype classification.<h4>Methods</h4>A total of 811 participants from 6 sites were included: probands with schizophrenia (n = 199), schizoaffective disorder (n = 122), psychotic bipolar disorder with psychosis (n = 160), and healthy controls (n = 330). Biotype classification, previously developed using cognitive and electrophysiological data and K-meanSchizophrenia bulletinA Diagnosis and Biotype Comparison Across the Psychosis Spectrum: Investigating Volume and Shape Amygdala-Hippocampal Differences from the B-SNIP Study.PMC8530385MH077945R01 MH077862MH078113UL1 TR001863MH077862MH077851Kelly SGuimond SClementz BAGu FTamminga CChakravarty MMKeshavan MMike LDevenyi GAPearlson GShannon HSweeney JAfalseA Diagnosis and Biotype Comparison Across the Psychosis Spectrum: Investigating Volume and Shape Amygdala-Hippocampal Differences from the B-SNIP Study.<h4>Objective</h4>Brain-based Biotypes for psychotic disorders have been developed as part of the B-SNIP consortium to create neurobiologically distinct subgroups within idiopathic psychosis, independent from traditional phenomenological diagnostic methods. In the current study, we aimed to validate the Biotype model by assessing differences in volume and shape of the amygdala and hippocampus contrasting traditional clinical diagnoses with Biotype classification.<h4>Methods</h4>A total of 811 participants from 6 sites were included: probands with schizophrenia (n = 199), schizoaffective disorder (n = 122), psychotic bipolar disorder with psychosis (n = 160), and healthy controls (n = 330). Biotype classification, previously developed using cognitive and electrophysiological data and K-mean2021-01-01T00:00:00Z2021 Oct2026-05-09T02:49:54.037Z2026-05-04T03:11:11.031ZS-EPMC85303853425414710.1093/schbul/sbab071