{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["113"],"submitter":["Hou X"],"funding":["Guangxi Natural Science Foundation","Guilin Science and Technology Bureau","China Postdoctoral Science Foundation","Guangxi Science and Technology Department"],"pubmed_abstract":["<h4>Objective</h4>Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing global health emergency. T-cell receptors (TCRs) are crucial mediators of antiviral adaptive immunity. This study sought to comprehensively characterize the TCR repertoire changes in patients with COVID-19.<h4>Methods</h4>A large sample size multi-center randomized controlled trial was implemented to study the features of the TCR repertoire and identify COVID-19 disease-related TCR sequences.<h4>Results</h4>It was found that some T-cell receptor beta chain (TCRβ) features differed markedly between COVID-19 patients and healthy controls, including decreased repertoire diversity, longer complementarity-determining region 3 (CDR3) length, skewed utilizat"],"journal":["International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases"],"pagination":["308-317"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8530772"],"repository":["biostudies-literature"],"pubmed_title":["T-cell receptor repertoires as potential diagnostic markers for patients with COVID-19."],"pmcid":["PMC8530772"],"pubmed_authors":["Liu H","Mo C","Wen X","Fan W","He D","Wang G","Mo L","Jiang S","Chen H","Hou X","Gong W","Ou M","Guo H","Chen X","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"T-cell receptor repertoires as potential diagnostic markers for patients with COVID-19.","description":"<h4>Objective</h4>Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing global health emergency. T-cell receptors (TCRs) are crucial mediators of antiviral adaptive immunity. This study sought to comprehensively characterize the TCR repertoire changes in patients with COVID-19.<h4>Methods</h4>A large sample size multi-center randomized controlled trial was implemented to study the features of the TCR repertoire and identify COVID-19 disease-related TCR sequences.<h4>Results</h4>It was found that some T-cell receptor beta chain (TCRβ) features differed markedly between COVID-19 patients and healthy controls, including decreased repertoire diversity, longer complementarity-determining region 3 (CDR3) length, skewed utilizat","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-22T20:49:02.077Z","creation":"2025-04-06T03:15:36.338Z"},"accession":"S-EPMC8530772","cross_references":{"pubmed":["34688948"],"doi":["10.1016/j.ijid.2021.10.033"]}}