biostudies-literatureUnknown113Hou XGuangxi Natural Science FoundationGuilin Science and Technology BureauChina Postdoctoral Science FoundationGuangxi Science and Technology Department<h4>Objective</h4>Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing global health emergency. T-cell receptors (TCRs) are crucial mediators of antiviral adaptive immunity. This study sought to comprehensively characterize the TCR repertoire changes in patients with COVID-19.<h4>Methods</h4>A large sample size multi-center randomized controlled trial was implemented to study the features of the TCR repertoire and identify COVID-19 disease-related TCR sequences.<h4>Results</h4>It was found that some T-cell receptor beta chain (TCRβ) features differed markedly between COVID-19 patients and healthy controls, including decreased repertoire diversity, longer complementarity-determining region 3 (CDR3) length, skewed utilizatInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases308-317https://www.ebi.ac.uk/biostudies/studies/S-EPMC8530772biostudies-literatureT-cell receptor repertoires as potential diagnostic markers for patients with COVID-19.PMC8530772Liu HMo CWen XFan WHe DWang GMo LJiang SChen HHou XGong WOu MGuo HChen XWang YfalseT-cell receptor repertoires as potential diagnostic markers for patients with COVID-19.<h4>Objective</h4>Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing global health emergency. T-cell receptors (TCRs) are crucial mediators of antiviral adaptive immunity. This study sought to comprehensively characterize the TCR repertoire changes in patients with COVID-19.<h4>Methods</h4>A large sample size multi-center randomized controlled trial was implemented to study the features of the TCR repertoire and identify COVID-19 disease-related TCR sequences.<h4>Results</h4>It was found that some T-cell receptor beta chain (TCRβ) features differed markedly between COVID-19 patients and healthy controls, including decreased repertoire diversity, longer complementarity-determining region 3 (CDR3) length, skewed utilizat2021-01-01T00:00:00Z2021 Dec2025-04-22T20:49:02.077Z2025-04-06T03:15:36.338ZS-EPMC85307723468894810.1016/j.ijid.2021.10.033