{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Fukushi I"],"pubmed_abstract":["Acute hypoxia increases ventilation. After cessation of hypoxia loading, ventilation decreases but remains above the pre-exposure baseline level for a time. However, the mechanism of this post-hypoxic persistent respiratory augmentation (PHRA), which is a short-term potentiation of breathing, has not been elucidated. We aimed to test the hypothesis that astrocytes are involved in PHRA. To this end, we investigated hypoxic ventilatory responses by whole-body plethysmography in unanesthetized adult mice. The animals breathed room air, hypoxic gas mixture (7% O<sub>2</sub>, 93% N<sub>2</sub>) for 2min, and again room air for 10min before and after i.p. administration of low (100mg/kg) and high (300mg/kg) doses of arundic acid (AA), an astrocyte inhibitor. AA suppressed PHRA, with the high dos"],"journal":["Frontiers in physiology"],"pagination":["757731"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8531090"],"repository":["biostudies-literature"],"pubmed_title":["Activation of Astrocytes in the Persistence of Post-hypoxic Respiratory Augmentation."],"pmcid":["PMC8531090"],"pubmed_authors":["Yoshizawa M","Fukushi I","Onimaru H","Okada Y","Mori Y","Kono Y","Nakao A","Takeda K","Hasebe Y","Pokorski M"],"additional_accession":[]},"is_claimable":false,"name":"Activation of Astrocytes in the Persistence of Post-hypoxic Respiratory Augmentation.","description":"Acute hypoxia increases ventilation. After cessation of hypoxia loading, ventilation decreases but remains above the pre-exposure baseline level for a time. However, the mechanism of this post-hypoxic persistent respiratory augmentation (PHRA), which is a short-term potentiation of breathing, has not been elucidated. We aimed to test the hypothesis that astrocytes are involved in PHRA. To this end, we investigated hypoxic ventilatory responses by whole-body plethysmography in unanesthetized adult mice. The animals breathed room air, hypoxic gas mixture (7% O<sub>2</sub>, 93% N<sub>2</sub>) for 2min, and again room air for 10min before and after i.p. administration of low (100mg/kg) and high (300mg/kg) doses of arundic acid (AA), an astrocyte inhibitor. AA suppressed PHRA, with the high dos","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-22T20:50:15.572Z","creation":"2025-04-06T03:18:15.557Z"},"accession":"S-EPMC8531090","cross_references":{"pubmed":["34690820"],"doi":["10.3389/fphys.2021.757731"]}}