{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Frorup C"],"funding":["Steno Diabetes Center Copenhagen (SDCC)","Novo Nordisk Fonden"],"pagination":["744509"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8531745"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["Type 1 diabetes is an immune-driven disease, where the insulin-producing beta cells from the pancreatic islets of Langerhans becomes target of immune-mediated destruction. Several studies have highlighted the implication of circulating and exosomal microRNAs (miRNAs) in type 1 diabetes, underlining its biomarker value and novel therapeutic potential. Recently, we discovered that exosome-enriched extracellular vesicles carry altered levels of both known and novel miRNAs in breast milk from lactating mothers with type 1 diabetes. In this study, we aimed to characterize exosomal miRNAs in the circulation of lactating mothers with and without type 1 diabetes, hypothesizing that differences in type 1 diabetes risk in offspring from these groups are reflected in the circulating miRNA profile. We"],"journal":["Frontiers in immunology"],"pubmed_title":["Plasma Exosome-Enriched Extracellular Vesicles From Lactating Mothers With Type 1 Diabetes Contain Aberrant Levels of miRNAs During the Postpartum Period."],"pmcid":["PMC8531745"],"funding_grant_id":["SDCC 3.D Type1 Biology","NNF14OC0009275"],"pubmed_authors":["Engelbrekt C","Storling J","Johannesen J","Pociot F","Mathiesen ER","Kaur S","Frorup C","Yarani R","Nielsen LB","Svare J","Mortensen HB","Damm P","Mirza AH"],"additional_accession":[]},"is_claimable":false,"name":"Plasma Exosome-Enriched Extracellular Vesicles From Lactating Mothers With Type 1 Diabetes Contain Aberrant Levels of miRNAs During the Postpartum Period.","description":"Type 1 diabetes is an immune-driven disease, where the insulin-producing beta cells from the pancreatic islets of Langerhans becomes target of immune-mediated destruction. Several studies have highlighted the implication of circulating and exosomal microRNAs (miRNAs) in type 1 diabetes, underlining its biomarker value and novel therapeutic potential. Recently, we discovered that exosome-enriched extracellular vesicles carry altered levels of both known and novel miRNAs in breast milk from lactating mothers with type 1 diabetes. In this study, we aimed to characterize exosomal miRNAs in the circulation of lactating mothers with and without type 1 diabetes, hypothesizing that differences in type 1 diabetes risk in offspring from these groups are reflected in the circulating miRNA profile. We","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-09T03:45:20.872Z","creation":"2025-02-19T01:44:07.287Z"},"accession":"S-EPMC8531745","cross_references":{"pubmed":["34691048"],"doi":["10.3389/fimmu.2021.744509"]}}