{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou J"],"funding":["Changzhou Health Commission"],"pagination":["8727924"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8531794"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2021"],"pubmed_abstract":["<h4>Background</h4>The CXC chemokines belong to a unique family of cytokines that participates in the progression and development of many malignant tumors. Evidence for the relationship between chemokine (C-X-C motif) receptor 2 (CXCR2) C1208T polymorphism and susceptibility to cancer remains inconsistent.<h4>Methods</h4>Odds ratios (ORs), 95% confidence intervals (CIs), and combined analysis were used to investigate the effect of CXCR2 variation on cancer risk. Gene Set Enrichment Analysis (GSEA) and enzyme-linked immunosorbent assay (ELISA) were also used to evaluate the expression of CXCR2 in prostate cancer (PCA).<h4>Results</h4>Across 11 case-control studies, 4,909 cases and 5,884 controls were involved in the current analysis. Individuals with a TT genotype were associated with incre"],"journal":["Journal of immunology research"],"pubmed_title":["Impacts of Chemokine (C-X-C Motif) Receptor 2 C1208T Polymorphism on Cancer Susceptibility."],"pmcid":["PMC8531794"],"funding_grant_id":["WZ201917"],"pubmed_authors":["Tang BW","Chen XP","Su QX","Shi XK","Zhao CP","Wang H","Zhou J","Wu H"],"additional_accession":[]},"is_claimable":false,"name":"Impacts of Chemokine (C-X-C Motif) Receptor 2 C1208T Polymorphism on Cancer Susceptibility.","description":"<h4>Background</h4>The CXC chemokines belong to a unique family of cytokines that participates in the progression and development of many malignant tumors. Evidence for the relationship between chemokine (C-X-C motif) receptor 2 (CXCR2) C1208T polymorphism and susceptibility to cancer remains inconsistent.<h4>Methods</h4>Odds ratios (ORs), 95% confidence intervals (CIs), and combined analysis were used to investigate the effect of CXCR2 variation on cancer risk. Gene Set Enrichment Analysis (GSEA) and enzyme-linked immunosorbent assay (ELISA) were also used to evaluate the expression of CXCR2 in prostate cancer (PCA).<h4>Results</h4>Across 11 case-control studies, 4,909 cases and 5,884 controls were involved in the current analysis. Individuals with a TT genotype were associated with incre","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-03-27T16:15:16.978Z","creation":"2025-05-18T10:37:48.742Z"},"accession":"S-EPMC8531794","cross_references":{"pubmed":["34692853"],"doi":["10.1155/2021/8727924"]}}