biostudies-literatureUnknown2021Kim EK<h4>Introduction</h4>The objective of this systematic review with meta-analysis is to determine whether prophylactic local antibiotics prevent surgical site infections (SSIs) in instrumented spinal fusions and traumatic fracture repair. A secondary objective is to investigate the effect of vancomycin, a common local antibiotic of choice, on the microbiology of SSIs.<h4>Methods</h4>An electronic search of PubMed, EMBASE, and Web of Science databases and major orthopedic surgery conferences was conducted to identify studies that (1) were instrumented spinal fusions or fracture repair and (2) had a treatment group that received prophylactic local antibiotics. Both randomized controlled trials (RCTs) and comparative observational studies were included. Meta-analysis was performed separately foAdvances in orthopedics1949877https://www.ebi.ac.uk/biostudies/studies/S-EPMC8531801biostudies-literatureProphylactic Topical Antibiotics in Fracture Repair and Spinal Fusion.PMC8531801Kim EKMorshed SDonnelley CAShearer DVon Kaeppler ERoberts HJTiee MfalseProphylactic Topical Antibiotics in Fracture Repair and Spinal Fusion.<h4>Introduction</h4>The objective of this systematic review with meta-analysis is to determine whether prophylactic local antibiotics prevent surgical site infections (SSIs) in instrumented spinal fusions and traumatic fracture repair. A secondary objective is to investigate the effect of vancomycin, a common local antibiotic of choice, on the microbiology of SSIs.<h4>Methods</h4>An electronic search of PubMed, EMBASE, and Web of Science databases and major orthopedic surgery conferences was conducted to identify studies that (1) were instrumented spinal fusions or fracture repair and (2) had a treatment group that received prophylactic local antibiotics. Both randomized controlled trials (RCTs) and comparative observational studies were included. Meta-analysis was performed separately fo2021-01-01T00:00:00Z20212026-04-19T03:12:48.31Z2025-04-04T10:55:29.558ZS-EPMC85318013469178310.1155/2021/1949877