biostudies-literatureUnknown12Brue T<h4>Objective</h4>Efficacy of pharmacological treatments for acromegaly has been assessed in many clinical or real-world studies but no study was interested in economics evaluation of these treatments in France. Therefore, the objective of this study was to estimate the cost-utility of second-line pharmacological treatments in acromegaly patients.<h4>Methods</h4>A Markov model was developed to follow a cohort of 1,000 patients for a lifetime horizon. First-generation somatostatin analogues (FGSA), pegvisomant, pasireotide and pegvisomant combined with FGSA (off label) were compared. Efficacy was defined as the normalization of insulin-like growth factor-1 (IGF-1) concentration and was obtained from pivotal trials and adjusted by a network meta-analysis. Costs data were obtained from FrenchFrontiers in endocrinology745843https://www.ebi.ac.uk/biostudies/studies/S-EPMC8531881biostudies-literatureCost-Utility of Acromegaly Pharmacological Treatments in a French Context.PMC8531881Drui DRaverot GRodien PHenocque RJuban LBrue TSalvi LMarie LDelemer BChanson PfalseCost-Utility of Acromegaly Pharmacological Treatments in a French Context.<h4>Objective</h4>Efficacy of pharmacological treatments for acromegaly has been assessed in many clinical or real-world studies but no study was interested in economics evaluation of these treatments in France. Therefore, the objective of this study was to estimate the cost-utility of second-line pharmacological treatments in acromegaly patients.<h4>Methods</h4>A Markov model was developed to follow a cohort of 1,000 patients for a lifetime horizon. First-generation somatostatin analogues (FGSA), pegvisomant, pasireotide and pegvisomant combined with FGSA (off label) were compared. Efficacy was defined as the normalization of insulin-like growth factor-1 (IGF-1) concentration and was obtained from pivotal trials and adjusted by a network meta-analysis. Costs data were obtained from French2021-01-01T00:00:00Z20212026-07-16T14:42:05.451Z2025-04-05T22:19:52.07ZS-EPMC85318813469093310.3389/fendo.2021.745843