{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(10)"],"submitter":["Baldwin Vi RL"],"pubmed_abstract":["We present an analysis of transcriptomic dynamics in rumen epithelium of 18 Holstein calves during the transition from pre-rumination to rumination in cattle-fed hay or concentrated diets at weaning. Three calves each were euthanized at 14 and 42 d of age to exemplify preweaning, and six calves each were provided diets of either milk replacer and grass hay or calf starter to introduce weaning. The two distinct phases of rumen development and function in cattle are tightly regulated by a series of signaling events and clusters of effectors on critical pathways. The dietary shift from liquid to solid feeds prompted the shifting of gene activity. The number of differentially expressed genes increased significantly after weaning. Bioinformatic analysis revealed gene activity shifts underline t"],"journal":["Animals : an open access journal from MDPI"],"pagination":["2870"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8532853"],"repository":["biostudies-literature"],"pubmed_title":["Transcriptional Reprogramming in Rumen Epithelium during the Developmental Transition of Pre-Ruminant to the Ruminant in Cattle."],"pmcid":["PMC8532853"],"pubmed_authors":["Liu M","Li CJ","Ramsay TG","Liu GE","Baldwin Vi RL","Connor EE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptional Reprogramming in Rumen Epithelium during the Developmental Transition of Pre-Ruminant to the Ruminant in Cattle.","description":"We present an analysis of transcriptomic dynamics in rumen epithelium of 18 Holstein calves during the transition from pre-rumination to rumination in cattle-fed hay or concentrated diets at weaning. Three calves each were euthanized at 14 and 42 d of age to exemplify preweaning, and six calves each were provided diets of either milk replacer and grass hay or calf starter to introduce weaning. The two distinct phases of rumen development and function in cattle are tightly regulated by a series of signaling events and clusters of effectors on critical pathways. The dietary shift from liquid to solid feeds prompted the shifting of gene activity. The number of differentially expressed genes increased significantly after weaning. Bioinformatic analysis revealed gene activity shifts underline t","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-20T02:04:02.539Z","creation":"2025-04-20T02:04:02.539Z"},"accession":"S-EPMC8532853","cross_references":{"pubmed":["34679891"],"doi":["10.3390/ani11102870"]}}