{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["You HJ"],"funding":["National Cancer Center","National Research Foundation of Korea"],"pagination":["1404"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8533394"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(10)"],"pubmed_abstract":["Androgen signaling via the androgen receptor (AR) is involved in normal prostate development and prostate cancer progression. In addition to androgen binding, a variety of protein kinases, including cyclic AMP-dependent protein kinase A (PKA), can activate the AR. Although hormone deprivation, especially that of androgen, continues to be an important strategy for treating prostate cancer patients, the disease ultimately progresses to castration-resistant prostate cancer (CRPC), despite a continuous hormone-deprived environment. To date, it remains unclear which pathways in this progression are active and targetable. Here, we performed a proteomic analysis of VCaP cells stimulated with androgen or forskolin to identify proteins specific for androgen-induced and androgen-bypassing signaling,"],"journal":["Biomedicines"],"pubmed_title":["Characterization of Proteins Regulated by Androgen and Protein Kinase a Signaling in VCaP Prostate Cancer Cells."],"pmcid":["PMC8533394"],"funding_grant_id":["NCC-2110521","2015R1C1A1A02036315, 2018R1A2B6001241, and 2021R1A2C2014147"],"pubmed_authors":["Song BS","You HJ","You BC","Kim JK","Park JM","Myung JK"],"additional_accession":[]},"is_claimable":false,"name":"Characterization of Proteins Regulated by Androgen and Protein Kinase a Signaling in VCaP Prostate Cancer Cells.","description":"Androgen signaling via the androgen receptor (AR) is involved in normal prostate development and prostate cancer progression. In addition to androgen binding, a variety of protein kinases, including cyclic AMP-dependent protein kinase A (PKA), can activate the AR. Although hormone deprivation, especially that of androgen, continues to be an important strategy for treating prostate cancer patients, the disease ultimately progresses to castration-resistant prostate cancer (CRPC), despite a continuous hormone-deprived environment. To date, it remains unclear which pathways in this progression are active and targetable. Here, we performed a proteomic analysis of VCaP cells stimulated with androgen or forskolin to identify proteins specific for androgen-induced and androgen-bypassing signaling,","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-05T13:58:30.472Z","creation":"2025-04-05T13:58:30.472Z"},"accession":"S-EPMC8533394","cross_references":{"pubmed":["34680521"],"doi":["10.3390/biomedicines9101404"]}}