{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(10)"],"submitter":["Campion O"],"pubmed_abstract":["<h4>Background</h4>LRP-1 is a multifunctional scavenger receptor belonging to the LDLR family. Due to its capacity to control pericellular levels of various growth factors and proteases, LRP-1 plays a crucial role in membrane proteome dynamics, which appears decisive for tumor progression.<h4>Methods</h4>LRP-1 involvement in a TNBC model was assessed using an RNA interference strategy in MDA-MB-231 cells. In vivo, tumorigenic and angiogenic effects of LRP-1-repressed cells were evaluated using an orthotopic xenograft model and two angiogenic assays (Matrigel<sup>®</sup> plugs, CAM). DCE-MRI, FMT, and IHC were used to complete a tumor longitudinal follow-up and obtain morphological and functional vascular information. In vitro, HUVECs' angiogenic potential was evaluated using a tumor secret"],"journal":["Biomedicines"],"pagination":["1430"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8533426"],"repository":["biostudies-literature"],"pubmed_title":["LRP-1 Matricellular Receptor Involvement in Triple Negative Breast Cancer Tumor Angiogenesis."],"pmcid":["PMC8533426"],"pubmed_authors":["Djermoune EH","Wahart A","Meunier M","Bikfalvi A","Dedieu S","Campion O","Etique N","Billottet C","Raymond AA","Thevenard Devy J","Schneider C","Lelievre E","Dupuy JW","Hachet C","Boulagnon Rombi C","Devy J","Bour C","Cairo S"],"additional_accession":[]},"is_claimable":false,"name":"LRP-1 Matricellular Receptor Involvement in Triple Negative Breast Cancer Tumor Angiogenesis.","description":"<h4>Background</h4>LRP-1 is a multifunctional scavenger receptor belonging to the LDLR family. Due to its capacity to control pericellular levels of various growth factors and proteases, LRP-1 plays a crucial role in membrane proteome dynamics, which appears decisive for tumor progression.<h4>Methods</h4>LRP-1 involvement in a TNBC model was assessed using an RNA interference strategy in MDA-MB-231 cells. In vivo, tumorigenic and angiogenic effects of LRP-1-repressed cells were evaluated using an orthotopic xenograft model and two angiogenic assays (Matrigel<sup>®</sup> plugs, CAM). DCE-MRI, FMT, and IHC were used to complete a tumor longitudinal follow-up and obtain morphological and functional vascular information. In vitro, HUVECs' angiogenic potential was evaluated using a tumor secret","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2026-04-08T06:50:17.661Z","creation":"2025-02-19T03:01:28.183Z"},"accession":"S-EPMC8533426","cross_references":{"pubmed":["34680548"],"doi":["10.3390/biomedicines9101430"]}}