biostudies-literatureUnknown9(10)Campion O<h4>Background</h4>LRP-1 is a multifunctional scavenger receptor belonging to the LDLR family. Due to its capacity to control pericellular levels of various growth factors and proteases, LRP-1 plays a crucial role in membrane proteome dynamics, which appears decisive for tumor progression.<h4>Methods</h4>LRP-1 involvement in a TNBC model was assessed using an RNA interference strategy in MDA-MB-231 cells. In vivo, tumorigenic and angiogenic effects of LRP-1-repressed cells were evaluated using an orthotopic xenograft model and two angiogenic assays (Matrigel^® plugs, CAM). DCE-MRI, FMT, and IHC were used to complete a tumor longitudinal follow-up and obtain morphological and functional vascular information. In vitro, HUVECs' angiogenic potential was evaluated using a tumor secretBiomedicines1430https://www.ebi.ac.uk/biostudies/studies/S-EPMC8533426biostudies-literatureLRP-1 Matricellular Receptor Involvement in Triple Negative Breast Cancer Tumor Angiogenesis.PMC8533426Djermoune EHWahart AMeunier MBikfalvi ADedieu SCampion OEtique NBillottet CRaymond AAThevenard Devy JSchneider CLelievre EDupuy JWHachet CBoulagnon Rombi CDevy JBour CCairo SfalseLRP-1 Matricellular Receptor Involvement in Triple Negative Breast Cancer Tumor Angiogenesis.<h4>Background</h4>LRP-1 is a multifunctional scavenger receptor belonging to the LDLR family. Due to its capacity to control pericellular levels of various growth factors and proteases, LRP-1 plays a crucial role in membrane proteome dynamics, which appears decisive for tumor progression.<h4>Methods</h4>LRP-1 involvement in a TNBC model was assessed using an RNA interference strategy in MDA-MB-231 cells. In vivo, tumorigenic and angiogenic effects of LRP-1-repressed cells were evaluated using an orthotopic xenograft model and two angiogenic assays (Matrigel^® plugs, CAM). DCE-MRI, FMT, and IHC were used to complete a tumor longitudinal follow-up and obtain morphological and functional vascular information. In vitro, HUVECs' angiogenic potential was evaluated using a tumor secret2021-01-01T00:00:00Z2021 Oct2026-04-08T06:50:17.661Z2025-02-19T03:01:28.183ZS-EPMC85334263468054810.3390/biomedicines9101430