biostudies-literatureGavrish GERussian Foundation for Basic Research1026https://www.ebi.ac.uk/biostudies/studies/S-EPMC8533512biostudies-literatureUnknown10(10)Conduct a reanalysis of transcriptome data for studying intracellular signaling or solving other experimental problems is becoming increasingly popular. Gene expression data are archived as microarray or RNA-seq datasets mainly in two public databases: Gene Expression Omnibus (GEO) and ArrayExpress (AE). These databases were not initially intended to systematically search datasets, making it challenging to conduct a secondary study. Therefore, we have created the ARGEOS service, which has the following advantages that facilitate the search: (1) Users can simultaneously send several requests that are supposed to be used for systematic searches, and it is possible to correct the requests; (2) advanced analysis of information about the dataset is available. The service collects detailed protoBiologyARGEOS: A New Bioinformatic Tool for Detailed Systematics Search in GEO and ArrayExpress.PMC853351219-29-01243Sergeeva MGGavrish GEChistyakov DVfalseARGEOS: A New Bioinformatic Tool for Detailed Systematics Search in GEO and ArrayExpress.Conduct a reanalysis of transcriptome data for studying intracellular signaling or solving other experimental problems is becoming increasingly popular. Gene expression data are archived as microarray or RNA-seq datasets mainly in two public databases: Gene Expression Omnibus (GEO) and ArrayExpress (AE). These databases were not initially intended to systematically search datasets, making it challenging to conduct a secondary study. Therefore, we have created the ARGEOS service, which has the following advantages that facilitate the search: (1) Users can simultaneously send several requests that are supposed to be used for systematic searches, and it is possible to correct the requests; (2) advanced analysis of information about the dataset is available. The service collects detailed proto2021-01-01T00:00:00Z2021 Oct2025-05-18T12:31:37.64Z2025-05-18T12:31:37.64ZS-EPMC85335123468112410.3390/biology10101026