{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Uzun S"],"funding":["Deutscher Akademischer Austauschdienst","Jean-Uhrmacher-Foundation, Cologne, Germany.","Deutsche Krebshilfe"],"pagination":["5221"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8533978"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(20)"],"pubmed_abstract":["VEGF signaling regulated by the vascular endothelial growth factor receptor 2 (VEGFR2) plays a decisive role in tumor angiogenesis, initiation and progression in several tumors including HNSCC. However, the impact of HPV-status on the expression of VEGFR2 in OPSCC has not yet been investigated, although HPV oncoproteins E6 and E7 induce VEGF-expression. In a series of 56 OPSCC with known HPV-status, VEGFR2 expression patterns were analyzed both in blood vessels from tumor-free and tumor-containing regions and within tumor cells by immunohistochemistry using densitometry. Differences in subcellular colocalization of VEGFR2 with endothelial, tumor and stem cell markers were determined by double-immunofluorescence imaging. Immunohistochemical results were correlated with clinicopathological d"],"journal":["Cancers"],"pubmed_title":["Comprehensive Analysis of VEGFR2 Expression in HPV-Positive and -Negative OPSCC Reveals Differing VEGFR2 Expression Patterns."],"pmcid":["PMC8533978"],"funding_grant_id":["70112727","91775528","NA"],"pubmed_authors":["Wuerdemann N","Donmez HG","Klussmann JP","Arolt C","Siefer OG","Uzun S","Hufbauer M","Puladi B","Huebbers CU","Korkmaz Y","Akgul B"],"additional_accession":[]},"is_claimable":false,"name":"Comprehensive Analysis of VEGFR2 Expression in HPV-Positive and -Negative OPSCC Reveals Differing VEGFR2 Expression Patterns.","description":"VEGF signaling regulated by the vascular endothelial growth factor receptor 2 (VEGFR2) plays a decisive role in tumor angiogenesis, initiation and progression in several tumors including HNSCC. However, the impact of HPV-status on the expression of VEGFR2 in OPSCC has not yet been investigated, although HPV oncoproteins E6 and E7 induce VEGF-expression. In a series of 56 OPSCC with known HPV-status, VEGFR2 expression patterns were analyzed both in blood vessels from tumor-free and tumor-containing regions and within tumor cells by immunohistochemistry using densitometry. Differences in subcellular colocalization of VEGFR2 with endothelial, tumor and stem cell markers were determined by double-immunofluorescence imaging. Immunohistochemical results were correlated with clinicopathological d","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2026-04-08T06:51:35.711Z","creation":"2025-04-19T08:23:42.282Z"},"accession":"S-EPMC8533978","cross_references":{"pubmed":["34680369"],"doi":["10.3390/cancers13205221"]}}