{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(10)"],"submitter":["Khawaja H"],"pubmed_abstract":["Inflammatory microenvironment after transplantation affects the proliferation and causes senescence of adipose-derived mesenchymal stem cells (hADMSCs) thus compromising their clinical efficacy. Priming stem cells with herbal extracts is considered very promising to improve their viability in the inflammatory milieu. Aesculus indica (A. indica) is used to treat many inflammatory diseases in Asia for decades. Herein, we explored the protective role of A. indica extract on human adipose-derived Mesenchymal Stem Cells (hADMSCs) against Monosodium Iodoacetate (MIA) induced stress in vitro. A. indica ameliorated the injury as depicted by significantly enhanced proliferation, viability, improved cell migration and superoxide dismutase activity. Furthermore, reduced lactate dehydrogenase activity"],"journal":["PloS one"],"pagination":["e0258762"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8535185"],"repository":["biostudies-literature"],"pubmed_title":["Protective and proliferative effect of Aesculus indica extract on stressed human adipose stem cells via downregulation of NF-κB pathway."],"pmcid":["PMC8535185"],"pubmed_authors":["Khawaja H","Yousaf MA","Yaqub F","Ahmad MR","Fazal N","Latief N","Hanif M"],"additional_accession":[]},"is_claimable":false,"name":"Protective and proliferative effect of Aesculus indica extract on stressed human adipose stem cells via downregulation of NF-κB pathway.","description":"Inflammatory microenvironment after transplantation affects the proliferation and causes senescence of adipose-derived mesenchymal stem cells (hADMSCs) thus compromising their clinical efficacy. Priming stem cells with herbal extracts is considered very promising to improve their viability in the inflammatory milieu. Aesculus indica (A. indica) is used to treat many inflammatory diseases in Asia for decades. Herein, we explored the protective role of A. indica extract on human adipose-derived Mesenchymal Stem Cells (hADMSCs) against Monosodium Iodoacetate (MIA) induced stress in vitro. A. indica ameliorated the injury as depicted by significantly enhanced proliferation, viability, improved cell migration and superoxide dismutase activity. Furthermore, reduced lactate dehydrogenase activity","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-04-08T09:02:30.933Z","creation":"2024-12-04T08:38:20.15Z"},"accession":"S-EPMC8535185","cross_references":{"pubmed":["34679084"],"doi":["10.1371/journal.pone.0258762"]}}