biostudies-literatureYu XStrategic Collaborative Innovation TeamNational Natural Science Funds of ChinaShanghai Three-year Action Plan for Public Health under Grant10980https://www.ebi.ac.uk/biostudies/studies/S-EPMC8535751biostudies-literatureUnknown18(20)<h4>Background</h4>Ensuring adherence guarantees the efficacy of pre-exposure prophylaxis (PrEP).<h4>Methods</h4>We conducted a cross-sectional study among 816 sexually transmitted infection (STI) patients in Shanghai. The questionnaire included self-reported demographic characteristics, self-administered items on adherence to free oral PrEP, and PrEP uptake behavior measurement. We conducted item analysis, reliability analysis, validity analysis and receiver operating characteristic (ROC) curve analysis.<h4>Results</h4>Not all items were considered acceptable in the item analysis. The questionnaire had a McDonald's ω coefficient of 0.847. The scale-level content validity index (CVI) was 0.938 and the item-level CVI of each item ranged from 0.750 to 1. In exploratory factor analysis, we introduced a four-factor model accounting for 79.838% of the aggregate variance, which was validated in confirmatory factor analysis. Adding PrEP adherence questionnaire scores contributed to prediction of PrEP uptake behavior (<i>p</i> < 0.001) in regression analysis. The maximum area under the ROC curve was 0.778 (95% IC: 0.739-0.817).<h4>Conclusion</h4>The PrEP adherence questionnaire presented psychometric validation among STI patients.International journal of environmental research and public healthPre-Exposure Prophylaxis (PrEP) Adherence Questionnaire: Psychometric Validation among Sexually Transmitted Infection Patients in China.PMC8535751SSMU-ZLCX20180601)71603166, 71673187GWV-10.2-XD13, GWV-10.1-XK15, GWV-10.1-XK18Ni YChang RGong RWang SXu CCai YWang HWang YYu XfalsePre-Exposure Prophylaxis (PrEP) Adherence Questionnaire: Psychometric Validation among Sexually Transmitted Infection Patients in China.<h4>Background</h4>Ensuring adherence guarantees the efficacy of pre-exposure prophylaxis (PrEP).<h4>Methods</h4>We conducted a cross-sectional study among 816 sexually transmitted infection (STI) patients in Shanghai. The questionnaire included self-reported demographic characteristics, self-administered items on adherence to free oral PrEP, and PrEP uptake behavior measurement. We conducted item analysis, reliability analysis, validity analysis and receiver operating characteristic (ROC) curve analysis.<h4>Results</h4>Not all items were considered acceptable in the item analysis. The questionnaire had a McDonald's ω coefficient of 0.847. The scale-level content validity index (CVI) was 0.938 and the item-level CVI of each item ranged from 0.750 to 1. In exploratory factor analysis, we introduced a four-factor model accounting for 79.838% of the aggregate variance, which was validated in confirmatory factor analysis. Adding PrEP adherence questionnaire scores contributed to prediction of PrEP uptake behavior (<i>p</i> < 0.001) in regression analysis. The maximum area under the ROC curve was 0.778 (95% IC: 0.739-0.817).<h4>Conclusion</h4>The PrEP adherence questionnaire presented psychometric validation among STI patients.2021-01-01T00:00:00Z2021 Oct2026-07-09T11:58:19.222Z2025-04-07T02:26:10.424ZS-EPMC85357513468273010.3390/ijerph182010980