biostudies-literatureMcRae KMMinistry of Business, Innovation and Employment1560https://www.ebi.ac.uk/biostudies/studies/S-EPMC8536008biostudies-literatureUnknown12(10)Facial eczema (FE) is a significant metabolic disease that affects New Zealand ruminants. Ingestion of the mycotoxin sporidesmin leads to liver and bile duct damage, which can result in photosensitisation, reduced productivity and death. Strategies used to manage the incidence and severity of the disease include breeding. In sheep, there is considerable genetic variation in the response to FE. A commercial testing program is available for ram breeders who aim to increase tolerance, determined by the concentration of the serum enzyme, gamma-glutamyltransferase 21 days after a measured sporidesmin challenge (GGT21). Genome-wide association studies were carried out to determine regions of the genome associated with GGT21. Two regions on chromosomes 15 and 24 are reported, which explain 5% andGenesGenomic Tools for the Identification of Loci Associated with Facial Eczema in New Zealand Sheep.PMC8536008OVIT0801Plowman JERowe SJAmyes NCBrauning RDodds KGDeb-Choudhury SBaird HJJohnson PLBixley MJMcRae KMMcEwan JCClarke SMCullen NGNewman SNfalseGenomic Tools for the Identification of Loci Associated with Facial Eczema in New Zealand Sheep.Facial eczema (FE) is a significant metabolic disease that affects New Zealand ruminants. Ingestion of the mycotoxin sporidesmin leads to liver and bile duct damage, which can result in photosensitisation, reduced productivity and death. Strategies used to manage the incidence and severity of the disease include breeding. In sheep, there is considerable genetic variation in the response to FE. A commercial testing program is available for ram breeders who aim to increase tolerance, determined by the concentration of the serum enzyme, gamma-glutamyltransferase 21 days after a measured sporidesmin challenge (GGT21). Genome-wide association studies were carried out to determine regions of the genome associated with GGT21. Two regions on chromosomes 15 and 24 are reported, which explain 5% and2021-01-01T00:00:00Z2021 Sep2026-05-03T03:15:55.39Z2025-02-19T00:28:01.917ZS-EPMC85360083468095510.3390/genes12101560