{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2021"],"submitter":["Sawai S"],"pubmed_abstract":["Schwann cells (SCs) are likely to be a vital component of cell-based therapies for nerve regeneration. There are various methods for inducing SC-like cells (SCLCs) from adipose-derived stem cells (ADSCs), but their phenotypic and functional characteristics remain unsatisfactory. Here, we report a novel efficient procedure to induce SCLCs by culturing ADSCs with ALK5 inhibitor (ALK5 i) II, a specific inhibitor of activin-like kinase 5 (ALK5) (transforming growth factor-<i>β</i> receptor 1 (TGF<i>β</i>R1)) that is also known as Repsox. The resultant cells that we named \"modified SCLCs (mSCLCs)\" expressed SC-specific genes more strongly than conventional SCLCs (cSCLCs) and displayed a neurosupportive capacity in vitro, similarly to genuine SCs. Regarding the mechanism of the mSCLC induction b"],"journal":["Stem cells international"],"pagination":["8307797"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8536445"],"repository":["biostudies-literature"],"pubmed_title":["ALK5 i II Accelerates Induction of Adipose-Derived Stem Cells toward Schwann Cells through a Non-Smad Signaling Pathway."],"pmcid":["PMC8536445"],"pubmed_authors":["Sawai S","Kishida T","Oda R","Tsuchida S","Mazda O","Sowa Y","Kotani SI","Fujiwara H","Takahashi K"],"additional_accession":[]},"is_claimable":false,"name":"ALK5 i II Accelerates Induction of Adipose-Derived Stem Cells toward Schwann Cells through a Non-Smad Signaling Pathway.","description":"Schwann cells (SCs) are likely to be a vital component of cell-based therapies for nerve regeneration. There are various methods for inducing SC-like cells (SCLCs) from adipose-derived stem cells (ADSCs), but their phenotypic and functional characteristics remain unsatisfactory. Here, we report a novel efficient procedure to induce SCLCs by culturing ADSCs with ALK5 inhibitor (ALK5 i) II, a specific inhibitor of activin-like kinase 5 (ALK5) (transforming growth factor-<i>β</i> receptor 1 (TGF<i>β</i>R1)) that is also known as Repsox. The resultant cells that we named \"modified SCLCs (mSCLCs)\" expressed SC-specific genes more strongly than conventional SCLCs (cSCLCs) and displayed a neurosupportive capacity in vitro, similarly to genuine SCs. Regarding the mechanism of the mSCLC induction b","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-06-02T21:51:10.003Z","creation":"2025-04-06T00:00:35.79Z"},"accession":"S-EPMC8536445","cross_references":{"pubmed":["34691193"],"doi":["10.1155/2021/8307797"]}}