{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Maltais R"],"funding":["Ministère de l'économie et de l'innovation du Québec"],"pagination":["11181"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8537847"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(20)"],"pubmed_abstract":["Aminosteroid derivative RM-581 was previously identified as an endoplasmic-reticulum (ER) stress inducer with potent in vitro and in vivo anticancer activities. We report its evaluation in androgen-independent prostate cancer (PC-3) cells. RM-581 efficiently blocks PC-3 cell proliferation with stronger activity than that of a selection of known antineoplastic agents. This later also showed a synergistic effect with docetaxel, able to block the proliferation of docetaxel-resistant PC-3 cells and, contrary to docetaxel, did not induce cell resistance. RM-581 induced an increase in the expression level of ER stress-related markers of apoptosis, potentially triggered by the presence of RM-581 in the ER of PC-3 cells. These in vitro results were then successfully translated in vivo in a PC-3 xe"],"journal":["International journal of molecular sciences"],"pubmed_title":["Induction of Endoplasmic Reticulum Stress-Mediated Apoptosis by Aminosteroid RM-581 Efficiently Blocks the Growth of PC-3 Cancer Cells and Tumors Resistant or Not to Docetaxel."],"pmcid":["PMC8537847"],"funding_grant_id":["N/A"],"pubmed_authors":["Roy J","Poirier D","Maltais R","Sato S","Perreault M","Levesque JC"],"additional_accession":[]},"is_claimable":false,"name":"Induction of Endoplasmic Reticulum Stress-Mediated Apoptosis by Aminosteroid RM-581 Efficiently Blocks the Growth of PC-3 Cancer Cells and Tumors Resistant or Not to Docetaxel.","description":"Aminosteroid derivative RM-581 was previously identified as an endoplasmic-reticulum (ER) stress inducer with potent in vitro and in vivo anticancer activities. We report its evaluation in androgen-independent prostate cancer (PC-3) cells. RM-581 efficiently blocks PC-3 cell proliferation with stronger activity than that of a selection of known antineoplastic agents. This later also showed a synergistic effect with docetaxel, able to block the proliferation of docetaxel-resistant PC-3 cells and, contrary to docetaxel, did not induce cell resistance. RM-581 induced an increase in the expression level of ER stress-related markers of apoptosis, potentially triggered by the presence of RM-581 in the ER of PC-3 cells. These in vitro results were then successfully translated in vivo in a PC-3 xe","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-20T02:02:14.468Z","creation":"2025-04-20T02:02:14.468Z"},"accession":"S-EPMC8537847","cross_references":{"pubmed":["34681843"],"doi":["10.3390/ijms222011181"]}}