biostudies-literatureDraxler AUniversität WienEuropean UnionNew Zealand Ministry of Business, Innovation and EmploymentInterreg SK-AT, NutriagingAgResearch Limited through the Strategic Science Investment Fund3479https://www.ebi.ac.uk/biostudies/studies/S-EPMC8537980biostudies-literatureUnknown13(10)A high protein intake at old age is important for muscle protein synthesis, however, this could also trigger protein oxidation with the potential risk for DNA damage. The aim of this study was to investigate whether an increased protein intake at recommended level or well above would affect DNA damage or change levels of reduced (GSH) and oxidised glutathione (GSSG) in community-dwelling elderly subjects. These analyses were performed in two randomized intervention studies, in Austria and in New Zealand. In both randomized control trials, the mean protein intake was increased with whole foods, in the New Zealand study (<i>n</i> = 29 males, 74.2 ± 3.6 years) to 1.7 g/kg body weight/d (10 weeks intervention; <i>p</i> < 0.001)) in the Austrian study (<i>n</i> = 119 males and females, 72.9 ± 4NutrientsThe Effect of Elevated Protein Intake on DNA Damage in Older People: Comparative Secondary Analysis of Two Randomized Controlled Trials.PMC8537980A19079 and A21246International Relationships grantIRSES-318962-BIOAGEV14Open Access Publishing Fund of the University of ViennaResearch Platform Acitve AgeingZohrer PADraxler ASharma PZeng NSjodin AMKodnar JNeubauer OFranzke BAschauer RStrasser EMRamzan FKnowles SOWessner BCameron-Smith DWagner KHMilan AMUnterberger SMitchell SMD'Souza RFRoy NCBragagna LMitchell CJCortolezis JTGillies NAfalseThe Effect of Elevated Protein Intake on DNA Damage in Older People: Comparative Secondary Analysis of Two Randomized Controlled Trials.A high protein intake at old age is important for muscle protein synthesis, however, this could also trigger protein oxidation with the potential risk for DNA damage. The aim of this study was to investigate whether an increased protein intake at recommended level or well above would affect DNA damage or change levels of reduced (GSH) and oxidised glutathione (GSSG) in community-dwelling elderly subjects. These analyses were performed in two randomized intervention studies, in Austria and in New Zealand. In both randomized control trials, the mean protein intake was increased with whole foods, in the New Zealand study (<i>n</i> = 29 males, 74.2 ± 3.6 years) to 1.7 g/kg body weight/d (10 weeks intervention; <i>p</i> < 0.001)) in the Austrian study (<i>n</i> = 119 males and females, 72.9 ± 42021-01-01T00:00:00Z2021 Sep2026-04-08T09:07:21.875Z2024-11-07T01:13:35.15ZS-EPMC85379803468448110.3390/nu13103479