{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lin CY"],"funding":["Ministry of Science and Technology, Taiwan","Chang Gung Medical Foundation"],"pagination":["11020"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8539319"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(20)"],"pubmed_abstract":["The α7-human papillomavirus (HPV)-related cervical squamous cell carcinoma (SCC) is associated with poor prognosis. We compared the genomic profiles of this disease in a cohort corresponding to the 2001-2014 period with various responses to radiotherapy or concurrent chemoradiation through microRNA (miR) profiling involving miR 4.0 array and human transcriptome array 2.0 analyses. A real-time quantitative polymerase chain reaction was then conducted to identify the predictive biomarkers. A significantly lower expression of miR143-3p in recurrent tumors (p = 0.0309) relative to that in nonrecurrent tumors was observed. The miR143-3p targeted the mRNA expression of the baculoviral inhibitor of the apoptosis protein (IAP) repeat-containing 2 (BIRC2; p = 0.0261). The BIRC2 protein levels (p = "],"journal":["International journal of molecular sciences"],"pubmed_title":["Inhibition of BIRC2 Sensitizes α7-HPV-Related Cervical Squamous Cell Carcinoma to Chemotherapy."],"pmcid":["PMC8539319"],"funding_grant_id":["CMRPG3F2241-3","MOST 104-2314-B-182-047-MY3"],"pubmed_authors":["Chang CB","Pan YB","Yang LY","Lai CH","Wang CC","Wu RC","Lin CY","Chao A"],"additional_accession":[]},"is_claimable":false,"name":"Inhibition of BIRC2 Sensitizes α7-HPV-Related Cervical Squamous Cell Carcinoma to Chemotherapy.","description":"The α7-human papillomavirus (HPV)-related cervical squamous cell carcinoma (SCC) is associated with poor prognosis. We compared the genomic profiles of this disease in a cohort corresponding to the 2001-2014 period with various responses to radiotherapy or concurrent chemoradiation through microRNA (miR) profiling involving miR 4.0 array and human transcriptome array 2.0 analyses. A real-time quantitative polymerase chain reaction was then conducted to identify the predictive biomarkers. A significantly lower expression of miR143-3p in recurrent tumors (p = 0.0309) relative to that in nonrecurrent tumors was observed. The miR143-3p targeted the mRNA expression of the baculoviral inhibitor of the apoptosis protein (IAP) repeat-containing 2 (BIRC2; p = 0.0261). The BIRC2 protein levels (p = ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-19T15:09:16.471Z","creation":"2025-04-19T15:09:16.471Z"},"accession":"S-EPMC8539319","cross_references":{"pubmed":["34681681"],"doi":["10.3390/ijms222011020"]}}