{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huber HF"],"funding":["National Institutes of Health"],"pagination":["1012"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8539335"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(10)"],"pubmed_abstract":["The emergence of SARS-CoV-2 variants is cause for concern, because these may become resistant to current vaccines and antiviral drugs in development. Current drugs target viral proteins, resulting in a critical need for RNA-targeted nanomedicines. To address this, a comparative analysis of SARS-CoV-2 variants was performed. Several highly conserved sites were identified, of which the most noteworthy is a partial homopurine palindrome site with >99% conservation within the coding region. This sequence was compared among recently emerged, highly infectious SARS-CoV-2 variants. Conservation of the site was maintained among these emerging variants, further contributing to its potential as a regulatory target site for SARS-CoV-2. RNAfold was used to predict the structures of the highly conserve"],"journal":["Pharmaceuticals (Basel, Switzerland)"],"pubmed_title":["Targeting SARS-CoV-2 Variants with Nucleic Acid Therapeutic Nanoparticle Conjugates."],"pmcid":["PMC8539335"],"funding_grant_id":["T35OD029981"],"pubmed_authors":["Huber HF","Delong RK","Millagaha Gedara NI","Nava-Chavez J","Jaberi-Douraki M","DeVader S","Xu X","Aparicio-Lopez C","Gaudreault NN"],"additional_accession":[]},"is_claimable":false,"name":"Targeting SARS-CoV-2 Variants with Nucleic Acid Therapeutic Nanoparticle Conjugates.","description":"The emergence of SARS-CoV-2 variants is cause for concern, because these may become resistant to current vaccines and antiviral drugs in development. Current drugs target viral proteins, resulting in a critical need for RNA-targeted nanomedicines. To address this, a comparative analysis of SARS-CoV-2 variants was performed. Several highly conserved sites were identified, of which the most noteworthy is a partial homopurine palindrome site with >99% conservation within the coding region. This sequence was compared among recently emerged, highly infectious SARS-CoV-2 variants. Conservation of the site was maintained among these emerging variants, further contributing to its potential as a regulatory target site for SARS-CoV-2. RNAfold was used to predict the structures of the highly conserve","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2026-06-13T03:23:21.746Z","creation":"2025-02-19T03:53:22.724Z"},"accession":"S-EPMC8539335","cross_references":{"pubmed":["34681236"],"doi":["10.3390/ph14101012"]}}