{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Van Nieuwenhuyse B"],"funding":["Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture"],"pagination":["1898"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8539586"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(10)"],"pubmed_abstract":["Phage therapy (PT) shows promising potential in managing biofilm infections, which include refractory orthopedic infections. We report the case of a 13-year-old girl who developed chronic polymicrobial biofilm infection of a pelvic bone allograft after Ewing's sarcoma resection surgery. Chronic infection by Clostridium hathewayi, Proteus mirabilis and Finegoldia magna was worsened by methicillin-susceptible Staphylococcus aureus exhibiting an inducible Macrolides-Lincosamides-Streptogramin B resistance phenotype (iMLSB). After failure of conventional conservative treatment, combination of in situ anti-S. aureus PT with surgical debridement and intravenous antibiotic therapy led to marked clinical and microbiological improvement, yet failed to prevent a recurrence of infection on the midter"],"journal":["Viruses"],"pubmed_title":["A Case of In Situ Phage Therapy against Staphylococcus aureus in a Bone Allograft Polymicrobial Biofilm Infection: Outcomes and Phage-Antibiotic Interactions."],"pmcid":["PMC8539586"],"funding_grant_id":["FC3689"],"pubmed_authors":["Van Nieuwenhuyse B","Chatzis O","Brichard B","Djebara S","Van der Linden D","Galant C","Docquier PL","Pirnay JP","Merabishvili M"],"additional_accession":[]},"is_claimable":false,"name":"A Case of In Situ Phage Therapy against Staphylococcus aureus in a Bone Allograft Polymicrobial Biofilm Infection: Outcomes and Phage-Antibiotic Interactions.","description":"Phage therapy (PT) shows promising potential in managing biofilm infections, which include refractory orthopedic infections. We report the case of a 13-year-old girl who developed chronic polymicrobial biofilm infection of a pelvic bone allograft after Ewing's sarcoma resection surgery. Chronic infection by Clostridium hathewayi, Proteus mirabilis and Finegoldia magna was worsened by methicillin-susceptible Staphylococcus aureus exhibiting an inducible Macrolides-Lincosamides-Streptogramin B resistance phenotype (iMLSB). After failure of conventional conservative treatment, combination of in situ anti-S. aureus PT with surgical debridement and intravenous antibiotic therapy led to marked clinical and microbiological improvement, yet failed to prevent a recurrence of infection on the midter","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-18T17:28:08.243Z","creation":"2025-04-07T04:59:01.553Z"},"accession":"S-EPMC8539586","cross_references":{"pubmed":["34696328"],"doi":["10.3390/v13101898"]}}