{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["He ZH"],"funding":["the National Natural Science Foundation of China"],"pagination":["580"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8540044"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(10)"],"pubmed_abstract":["A systematic chemical investigation of the deep-sea-derived fungus Penicillium solitum MCCC 3A00215 resulted in the isolation of one novel polyketide (1), two new alkaloids (2 and 3), and 22 known (4-25) compounds. The structures of the new compounds were established mainly on the basis of exhaustive analysis of 1D and 2D NMR data. Viridicatol (13) displayed moderate anti-tumor activities against PANC-1, Hela, and A549 cells with IC50 values of around 20 μM. Moreover, 13 displayed potent in vitro anti-food allergic activity with an IC50 value of 13 μM, compared to that of 92 μM for the positive control, loratadine, while indole-3-acetic acid methyl ester (9) and penicopeptide A (10) showed moderate effects (IC50 = 50 and 58 μM, respectively)."],"journal":["Marine drugs"],"pubmed_title":["Chemical Constituents of the Deep-Sea-Derived Penicillium solitum."],"pmcid":["PMC8540044"],"funding_grant_id":["21877022","DY135-B2-08"],"pubmed_authors":["Xu L","Yang XW","Wu J","Hu MY","He ZH","Li SJ","Shao ZZ","Xie MM","Hao YJ"],"additional_accession":[]},"is_claimable":false,"name":"Chemical Constituents of the Deep-Sea-Derived Penicillium solitum.","description":"A systematic chemical investigation of the deep-sea-derived fungus Penicillium solitum MCCC 3A00215 resulted in the isolation of one novel polyketide (1), two new alkaloids (2 and 3), and 22 known (4-25) compounds. The structures of the new compounds were established mainly on the basis of exhaustive analysis of 1D and 2D NMR data. Viridicatol (13) displayed moderate anti-tumor activities against PANC-1, Hela, and A549 cells with IC50 values of around 20 μM. Moreover, 13 displayed potent in vitro anti-food allergic activity with an IC50 value of 13 μM, compared to that of 92 μM for the positive control, loratadine, while indole-3-acetic acid methyl ester (9) and penicopeptide A (10) showed moderate effects (IC50 = 50 and 58 μM, respectively).","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-04T07:20:12.348Z","creation":"2025-04-04T07:20:12.348Z"},"accession":"S-EPMC8540044","cross_references":{"pubmed":["34677479"],"doi":["10.3390/md19100580"]}}