biostudies-literatureHe ZHthe National Natural Science Foundation of China580https://www.ebi.ac.uk/biostudies/studies/S-EPMC8540044biostudies-literatureUnknown19(10)A systematic chemical investigation of the deep-sea-derived fungus Penicillium solitum MCCC 3A00215 resulted in the isolation of one novel polyketide (1), two new alkaloids (2 and 3), and 22 known (4-25) compounds. The structures of the new compounds were established mainly on the basis of exhaustive analysis of 1D and 2D NMR data. Viridicatol (13) displayed moderate anti-tumor activities against PANC-1, Hela, and A549 cells with IC50 values of around 20 μM. Moreover, 13 displayed potent in vitro anti-food allergic activity with an IC50 value of 13 μM, compared to that of 92 μM for the positive control, loratadine, while indole-3-acetic acid methyl ester (9) and penicopeptide A (10) showed moderate effects (IC50 = 50 and 58 μM, respectively).Marine drugsChemical Constituents of the Deep-Sea-Derived Penicillium solitum.PMC854004421877022DY135-B2-08Xu LYang XWWu JHu MYHe ZHLi SJShao ZZXie MMHao YJfalseChemical Constituents of the Deep-Sea-Derived Penicillium solitum.A systematic chemical investigation of the deep-sea-derived fungus Penicillium solitum MCCC 3A00215 resulted in the isolation of one novel polyketide (1), two new alkaloids (2 and 3), and 22 known (4-25) compounds. The structures of the new compounds were established mainly on the basis of exhaustive analysis of 1D and 2D NMR data. Viridicatol (13) displayed moderate anti-tumor activities against PANC-1, Hela, and A549 cells with IC50 values of around 20 μM. Moreover, 13 displayed potent in vitro anti-food allergic activity with an IC50 value of 13 μM, compared to that of 92 μM for the positive control, loratadine, while indole-3-acetic acid methyl ester (9) and penicopeptide A (10) showed moderate effects (IC50 = 50 and 58 μM, respectively).2021-01-01T00:00:00Z2021 Oct2025-04-04T07:20:12.348Z2025-04-04T07:20:12.348ZS-EPMC85400443467747910.3390/md19100580