{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zanolla D"],"funding":["National Science Center Poland"],"pagination":["1606"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8540171"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(10)"],"pubmed_abstract":["Two new solvates of the widely used anthelminthic Praziquantel (PZQ) were obtained through mechanochemical screening with different liquid additives. Specifically, 2-pyrrolidone and acetic acid gave solvates with 1:1 stoichiometry (PZQ-AA and PZQ-2P, respectively). A wide-ranging characterization of the new solid forms was carried out by means of powder X-ray diffraction, differential scanning calorimetry, FT-IR, solid-state NMR and biopharmaceutical analyses (solubility and intrinsic dissolution studies). Besides, the crystal structures of the two new solvates were solved from their Synchrotron-PXRD pattern: the solvates are isostructural, with equivalent triclinic packing. In both structures acetic acid and 2-pyrrolidone showed a strong interaction with the PZQ molecule via hydrogen bond"],"journal":["Pharmaceutics"],"pubmed_title":["Mechanochemical Synthesis and Physicochemical Characterization of Previously Unreported Praziquantel Solvates with 2-Pyrrolidone and Acetic Acid."],"pmcid":["PMC8540171"],"funding_grant_id":["2018/31/D/ST5/03619"],"pubmed_authors":["Zanolla D","Hasa D","Arhangelskis M","Perissutti B","Voinovich D","Jones W","Gigli L","Demitri N","Chierotti MR"],"additional_accession":[]},"is_claimable":false,"name":"Mechanochemical Synthesis and Physicochemical Characterization of Previously Unreported Praziquantel Solvates with 2-Pyrrolidone and Acetic Acid.","description":"Two new solvates of the widely used anthelminthic Praziquantel (PZQ) were obtained through mechanochemical screening with different liquid additives. Specifically, 2-pyrrolidone and acetic acid gave solvates with 1:1 stoichiometry (PZQ-AA and PZQ-2P, respectively). A wide-ranging characterization of the new solid forms was carried out by means of powder X-ray diffraction, differential scanning calorimetry, FT-IR, solid-state NMR and biopharmaceutical analyses (solubility and intrinsic dissolution studies). Besides, the crystal structures of the two new solvates were solved from their Synchrotron-PXRD pattern: the solvates are isostructural, with equivalent triclinic packing. In both structures acetic acid and 2-pyrrolidone showed a strong interaction with the PZQ molecule via hydrogen bond","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-18T17:28:02.385Z","creation":"2025-04-07T04:58:56.056Z"},"accession":"S-EPMC8540171","cross_references":{"pubmed":["34683899"],"doi":["10.3390/pharmaceutics13101606"]}}